Evidence map›Paper›PMID 42179677›Full record

ArticleMolecular therapy. Advances2026

Continuous production of recombinant adeno-associated virus in the insect cell/baculovirus expression vector system.

John Joseph, Francesco Destro, Arella Yuan, Daniel Antov, Wenyu Chen, Sally Song, Matthew Theriault, Chengcheng Yuan, Alexander Sansom, Chiara Lundin and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

John JosephCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Francesco DestroDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Arella YuanCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Daniel AntovCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wenyu ChenCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sally SongCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Matthew TheriaultCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Chengcheng YuanCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alexander SansomCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Chiara LundinCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Tyler BurnsCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hadeel Abubaker HamedCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Piero MoralesCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jessica Xinyuan FanCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Avner Romero RodriguezCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sanyambe SichumaCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Courtney McCrackenCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Caleb NeufeldCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jacqueline M WolfrumCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Prasanna SrinivasanCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Paul W BaroneCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Anthony J SinskeyCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Richard D BraatzCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.
Stacy L SpringsCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous production processes may offer significant advantages for biotherapeutic manufacturing, including increased productivity, more consistent product quality, reduced facility footprint, and decreased process turnaround time. Despite these benefits, the

Indexed as

continuous manufacturingdefective interfering particlesmechanistic modelingrecombinant AAVSf9/BEVS

Identifiers

PMID42179677
PMCPMC13195323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.