Evidence map›Paper›PMID 42179665›Full record

ReviewBeyoglu eye journal2026

The Use of Citicoline in Ophthalmology: A systematic review.

Erel Icel, Okan Akmaz

Abstract readReview
In one paragraph

Review in Beyoglu eye journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erel IcelDepartment of Ophthalmology, Izmir City Hospital, Izmir, Türkiye.
Okan AkmazDepartment of Ophthalmology, Izmir City Hospital, Izmir, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Citicoline is a chemical molecule, and it plays a crucial role in the biosynthesis of cell membranes and has many functions in the human body. This compound, which increases the amount of neurotransmitters, is used in the treatment of various diseases in ophthalmology, neurology, and psychiatry. Its use as a supplement to improve cognitive functions is also widespread. In this review, we aim to shed light on the neuroprotective effects of citicoline and its applications in the field of ophthalmology, based on data obtained from published studies. Methods: In the literature, the effects of citicoline in various ophthalmological diseases have been mentioned; however, there is no clear consensus regarding its dosage, duration of use, or efficacy due to the limited number of published studies and designs of these studies. Upon reviewing the current studies, we found evidence suggesting that citicoline supplementation may be effective in amblyopia, glaucoma, and non-arteritic ischemic optic neuropathy. Conclusion: This review aims to evaluate and summarize the current evidence on the neuroprotective effects of citicoline in ophthalmologic diseases. Findings from various clinical studies suggest that it may have a beneficial effect on the treatment of conditions including amblyopia, glaucoma, and non-arteritic ischemic optic neuropathy.

Indexed as

AmblyopiaCDP-cholineciticolineglaucomanon-arteritic ischemic optic neuropathy

Identifiers

PMID42179665
PMCPMC13191348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.