Evidence map›Paper›PMID 42179658›Full record

ArticleResults in chemistry2025

A diatrizoic acid derivative for

Kousaku Ohkawa, Hemdeep Kaur, Tracy Nguyen, Beatrice Mae Malvar, Rebecca Back, Chloe Jin, Parisa Khosropour, Shuichi Suzuki, Frank P K Hsu, Ichiro Yuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Results in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kousaku OhkawaDivision of Synthetic Polymers, Institute of High Polymer Research, Faculty of Textile Science and Technology, Shinshu University, Tokida 3-15-1, Ueda 386-8567, Japan.
Hemdeep KaurDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.
Tracy NguyenDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.
Beatrice Mae MalvarDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.
Rebecca BackDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.
Chloe JinDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.
Parisa KhosropourAquaTeX Medical, Inc., Irvine CA92617, USA.
Shuichi SuzukiDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.
Frank P K HsuDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.
Ichiro YukiDepartment of Neurological Surgery, University of California, Irvine, 200S Manchester St., Suite 210, Orange CA92868, USA.

Funding

Water-based liquid embolic agent for the treatment of vascular rich tumorsR41CA277860 · NCI · AQUATEX MEDICAL, INC. · PI YUKI, ICHIRO · 2023 to 2023
$400k
NCI NIH HHS R41 CA277860
6 · The paper itself

Abstract

3,5-Bis(acetamido)-2,4,6-triiodobenzoic acid, aka diatrizoic acid (DTZOH), is a major compound for the radiopaque material research. Iodine elements at the 2,4,6-positions are the origin of the radiopacity, but the bulkiness of iodine frequently inhibits the nucleophilic attack to the 1-carboxylic carbon, resulting in a low yield when DTZOH is used as an acylation agent. In this study, the authors hypothesized that the 1-carboxylic oxygen is utilized as a nucleophile because of its freedom from iodine-shielding. The base-catalyzed esterification using

Indexed as

Conformer search calculationDiatrizoic acid derivativesN-acylation of amino acid derivatives

Identifiers

PMID42179658
PMCPMC13193223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.