Evidence map›Paper›PMID 42179603›Full record

ReviewACS omega2026

Lycopene as Medicine: Unlocking the Therapeutic Power of a Bioactive Carotenoid.

Farid Hajareh Haghighi, Roya Binaymotlagh, Paula Stefana Pintilei, Laura Chronopoulou, Cleofe Palocci

Abstract readReview
In one paragraph

Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Farid Hajareh HaghighiDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Roya BinaymotlaghDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Paula Stefana PintileiDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Laura ChronopoulouDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Cleofe PalocciDepartment of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.ORCID https://orcid.org/0000-0001-5583-8941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lycopene, a naturally occurring carotenoid predominantly found in tomatoes and other red fruits, has attracted growing scientific interest due to its potent bioactive properties and wide-ranging therapeutic potential. This mini-review delves into the multifaceted role of lycopene in human health, with particular emphasis on its antioxidant, anti-inflammatory, and metabolic regulatory functions. We present its applications across a broad spectrum of conditions, including cardiovascular disease, cancer, metabolic disorders, reproductive health, neurodegenerative diseases, eye health, and viral infections. Special attention is given to recent advancements in nanoformulated lycopene delivery systems designed to address challenges in bioavailability and enhance targeted therapeutic efficacy. Additionally, we discuss safety profiles, dosage considerations, and regulatory frameworks relevant to lycopene-based interventions. Despite encouraging findings, significant gaps remain in long-term clinical data and the standardization of formulations. This review highlights lycopene's promise as a versatile therapeutic agent and advocates for continued interdisciplinary research to facilitate its translation into effective clinical applications.

Identifiers

PMID42179603
PMCPMC13191698

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.