ArticleACS omega2026
Halogenated Reagents in the Ugi Reaction: From Rearrangement Reactions to Ketal Synthesis.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
The morpholine scaffold constitutes a privileged structural motif in medicinal chemistry, although access to conformationally restricted systems remains challenging. Herein, we report a simple and efficient Ugi/postcondensation strategy that, for the first time, combines two aliphatic halogenated reagents with arylglyoxals to afford fused and bridged morpholines bearing ketal functionalities in a diastereoselective manner. These derivatives serve as precursors to 4-hydroxypyroglutamic acid derivatives, highlighting the synthetic versatility of the approach and providing rapid entry to structurally complex heterocyclic derivatives.
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Registered trials
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