Evidence map›Paper›PMID 42179566›Full record

ArticleACS omega2026

Islet Proteome Remodeling and Proteostasis Disruption in HFSC-Fed Mice.

Vijayalakshmi Gangadhara, Yalpi Karthik, Ravichandran Manisekaran, Asha Abraham

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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vijayalakshmi GangadharaFather George Albuquerque Pai Cell and Molecular Biology Laboratory, Department of Biotechnology, School of Life Sciences, St Aloysius (Deemed to be University), Mangaluru 575003, Karnataka, India.
Yalpi KarthikAgrogenomic Sciences, National School of Higher Studies Unit-León, National Autonomous University of Mexico (UNAM), C.P. 37689 León, Guanajuato, Mexico.
Ravichandran ManisekaranInterdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, Escuela, Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México (UNAM), Predio el Saucillo y el Potrero, Comunidad de los Tepetates, León C.P. 37684, Mexico.ORCID https://orcid.org/0000-0002-2934-0717
Asha AbrahamFather George Albuquerque Pai Cell and Molecular Biology Laboratory, Department of Biotechnology, School of Life Sciences, St Aloysius (Deemed to be University), Mangaluru 575003, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic overnutrition promotes metabolic syndrome and imposes substantial stress on pancreatic tissue, yet the early molecular alterations within pancreatic islets remain incompletely understood. High-fat, simple-carbohydrate (HFSC) diets have previously been shown to induce pancreatic steatosis, acinar atrophy, and islet hypertrophy in C57BL/6J mice. To investigate molecular responses underlying HFSC-induced pancreatic remodeling, we analyzed proteomic alterations in collagenase-isolated pancreatic islets from male C57BL/6J mice fed a laboratory-formulated HFSC diet for 150 days (

Identifiers

PMID42179566
PMCPMC13191665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.