Evidence map›Paper›PMID 42179458›Full record

ReviewThe EPMA journal2026

Thermoregulation and associated disorders: 3PM-guided holistic approach bridging innovative and traditional Chinese medicine.

Zhuo Wang, Hongtao Liu, Yueqiang Xu, Weijie Cao, Youxin Wang, Haifeng Hou, Xiuhua Guo, Olga Golubnitschaja, Wei Wang, Yuguang Du and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The EPMA journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhuo Wang *Glyco-Bioengineering Group, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China.
Hongtao Liu *Li Shizhen Institute, Hubei University of Chinese Medicine, Wuhan, China.
Yueqiang Xu *Beijing BAHEAL GLYCOMTECH Co., Ltd, Bejing, China.
Weijie CaoNutrition & Health Innovation Research Institute & School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.
Youxin WangSchool of Public Health, North China University of Science and Technology, Tangshan, China.
Haifeng HouSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
Xiuhua GuoBeijing BAHEAL GLYCOMTECH Co., Ltd, Bejing, China.
Olga GolubnitschajaPredictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
Wei WangInstitute for Glycome Study, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.
Yuguang DuGlyco-Bioengineering Group, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China.
Suboptimal Health Study Consortium, European Association for Predictive, Preventive, Personalised Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurately performed thermoregulation is life-important for the human body. Therefore, a relatively narrow temperature range of 36.5-37 °C, which all our biochemical reactions are adapted to, is rigorously kept by the body allowing for the most effective kinetics of all physiological processes. In contrast, feeling inappropriately cold or too hot in the environment with comfortable temperature ranges are symptoms of an altered or even disordered thermoregulation described for a number of syndromes as well as patient cohorts. The rationale of the paper is to contribute to the paradigm shift from reactive to proactive healthcare considering thermoregulation deficits as an important diagnostic and prognostic indicator to be explored and utilized for patient phenotyping and stratification followed by tailored treatment algorithms in primary and secondary care. The conceptual framework of Graphical Abstract: A left-right Cold (Yin) to Heat (Yang) continuum integrates layered regulation from genetics, epigenetics, and glycobiology through TRP/ion channels to cytokine-driven clinical phenotypes, visually unifying TCM theory with modern molecular biotechnology.

Indexed as

Cold–Heat syndromesEpigeneticsGlycobiologyHolistic approachImproved individual outcomesIndividualized patient profileIon channelsParadigm shift from reactive to proactive healthcarePatient phenotyping and stratificationPredictive Preventive Personalized Medicine (PPPM / 3PM)Systemic effectsTraditional Chinese MedicineTRP channelsYin–Yang

Identifiers

PMID42179458
PMCPMC13191007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.