Evidence map›Paper›PMID 42179226›Full record

SynthesisInternational journal of methods in psychiatric research2026

Suicide Risk Among Transgender Adolescents and Young Adults: A Meta-Analysis of Nearly One Million Participants.

Noheir Ashraf Ibrahem Fathy Hassan, Eman A Toraih, Menna A Shebl, Amaan Usmani, Uday Atwal, Ayesha Laraib-Ijaz, Helen A O Samuel, Ahmed Ibrahim Eldessouky, Anwar Alhouli, Yusuf Elsawah and 5 more

Abstract readComparative StudyMeta-Analysis
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Synthesis in International journal of methods in psychiatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Noheir Ashraf Ibrahem Fathy HassanFaculty of Medicine, Aswan University, Aswan, Egypt.
Eman A ToraihDepartment of Cardiovascular Perfusion, Upstate Medical University, Syracuse, New York, USA.ORCID 0000-0001-9267-3787
Menna A SheblModern University for Technology and Information, Cairo, Egypt.
Amaan UsmaniSkaneateles Central High School, Skaneateles, New York, USA.
Uday AtwalFayetteville-Manlius High School, Manlius, New York, USA.
Ayesha Laraib-IjazAyub Medical College, Abbottabad, Pakistan.
Helen A O SamuelSt. George University School of Medicine, St. George's, Grenada.
Ahmed Ibrahim EldessoukyFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Anwar AlhouliAl-Sagar Medical Center, Kuweit City, Kuwait.
Yusuf ElsawahAston Medical School, Aston University, Birmingham, UK.
Sonnet SunnyCaritas Hospital and Institute of Medical Science, Thellakom, India.
Muaaz AslamSheikh Khalifa Bin Zayed Al Nahyan Medical and Dental College, Lahore, Pakistan.
Jaafer ShahWeill Cornell Medicine, New York, New York, USA.
Yusef HazimehDepartment of Internal Medicine, Division of Endocrinology, American University of Beirut, Beirut, Lebanon.
Hani AiashDepartment of Cardiovascular Perfusion, Upstate Medical University, Syracuse, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMental health disparities among transgender and gender diverse adolescents and young adults represent a critical public health concern. This meta-analysis examined suicidal risk among transgender youth compared to their cisgender peers.

methodsFollowing PRISMA guidelines, we analyzed 29 studies published between 2015-2024, comprising nearly one million participants (957,163; 29,041 transgender and 928,122 cisgender). Random effects models were used to calculate risk ratios (RR) and prevalence estimates for suicidal ideation, planning, attempts, and completion.

resultsTransgender youth showed significantly higher prevalence of suicidal ideation (transmale: 52.2%, transfemale: 49.5% vs. cismale: 18.1%, cisfemale: 22.4%; p < 0.001) and attempts (48.0%-51.3% vs. 18.0%-22.0%; p < 0.001). Risk analyses revealed elevated risks for ideation (RR = 2.38, 95% CI: 1.97-2.88), attempts (RR = 2.85, 95% CI: 1.31-6.21), and completed suicide (RR = 4.80, 95% CI: 2.15-10.74). However, substantial heterogeneity was observed across all suicide outcomes (I

conclusionOverall, this meta-analysis documents markedly elevated suicidality among transgender adolescents and young adults, while emphasizing the need for cautious interpretation of aggregated effect sizes and further high-quality longitudinal research.

Indexed as

Suicidal IdeationSuicide, AttemptedTransgender PersonsAdolescentFemaleHumansMaleYoung Adultgender identitymental healthmeta‐analysissuicide risktransgenderyouth

Identifiers

PMID42179226
PMCPMC13240427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.