ArticleJournal of clinical laboratory analysis2026
Longitudinal Changes in the Serum Pepsinogen I/II Ratio With Progression of Gastric Atrophy.
Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Longitudinal Changes in the Serum Pepsinogen I/II Ratio With Progression of Gastric Atrophy.Journal of clinical laboratory analysis · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThis study evaluated longitudinal changes in the serum pepsinogen (PG) I/II ratio according to endoscopic gastric mucosal atrophy.
methodsWe retrospectively analyzed 21,265 participants who underwent endoscopy during health checkups between 2015 and 2023. Longitudinal changes in PG I/II ratio were examined in 2217 subjects with ≥ 2 endoscopies using linear mixed-effects models. Serum PG I, PG II, and Helicobacter pylori IgG were measured. The AG severity was graded endoscopically according to Kimura-Takemoto classification.
resultsThe PG I/II ratio decreased stepwise with advancing Kimura-Takemoto stage. In longitudinal analyses of 2217 participants with repeated endoscopy, within-subject declines in the PG I/II ratio paralleled progression of endoscopic atrophy, with greater reductions in more advanced stages (No atrophy: reference; C2: -0.383; C3: -1.150; O1: -1.412; O2: -2.101; O3: -2.007; all p < 0.001).
conclusionsWithin-subject declines in the PG I/II ratio were observed with progression of gastric atrophy. Serial measurement of the PG I/II ratio may be useful for monitoring the progression of gastric mucosal atrophy, particularly in patients for whom repeated endoscopic evaluation is not feasible.
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