ArticleJournal of clinical laboratory analysis2026
Performance Evaluation of a Premier Resolution HPLC System for Detecting Hemoglobin Constant Spring, Hemoglobin Paksé, and Coexisting α- and β-Thalassemia Mutations.
Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHemoglobin Constant Spring (HbCS) and Hb Paksé are clinically significant α-globin variants prevalent in Southeast Asia that cause severe non-deletional HbH disease when combined with α
methodsA two-phase validation study was conducted. Phase 1 analyzed 616 samples (307 DNA-confirmed HbCS/Hb Paksé cases) to characterize chromatographic patterns and compare Premier Resolution with CE. Phase 2 prospectively validated the system in 2032 consecutive individuals undergoing routine health screening. Molecular analysis served as the reference standard.
resultsPremier Resolution HPLC demonstrated distinctive multi-peak patterns spanning the S and C chromatographic windows for HbCS/Hb Paksé, with quantification limited to homozygous and α
conclusionsPremier Resolution HPLC provides a reliable and cost-effective method for HbCS detection in α-thalassemia-risk populations. Its enhanced resolution and characteristic chromatographic patterns support routine thalassemia screening in high-prevalence regions, though molecular confirmation remains necessary in heterozygous cases for genetic counseling.
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