ArticleJournal of enzyme inhibition and medicinal chemistry2026
Design and Pictet-Spengler enabled synthesis of carboxamide-substituted imidazo[1,2-
Joydeep Chatterjee, Gaurav Joshi, Vibhu Jha, Shivkanya M Bhujbal, Shivani Rathour, Sanjana Majumdar, Muhammad Wahajuddin, Prasad V Bharatam, Raj Kumar
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In one paragraphArticle in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
Joydeep ChatterjeeLaboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences, Central University of Punjab, Bathinda, India.
Gaurav JoshiDepartment of Pharmaceutical Science, Hemvati Nandan Bahuguna Garhwal (A Central) University, Srinagar, India.
Vibhu JhaInstitute of Cancer Therapeutics, School of Pharmacy, Optometry and Medical Sciences, University of Bradford, Bradford, UK.ORCID 0000-0002-1168-7480 Shivkanya M BhujbalDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India.
Shivani RathourLaboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences, Central University of Punjab, Bathinda, India.
Sanjana MajumdarLaboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences, Central University of Punjab, Bathinda, India.
Muhammad WahajuddinInstitute of Cancer Therapeutics, School of Pharmacy, Optometry and Medical Sciences, University of Bradford, Bradford, UK.
Prasad V BharatamDepartment of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India.
Raj KumarLaboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Health Sciences, Central University of Punjab, Bathinda, India.ORCID 0000-0001-5113-6627 Funding
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6 · The paper itselfAbstract
In this study, we report the Pictet-Spengler enabled synthesis of a series of eighteen carboxamide-substituted imidazo[1,2-
Indexed as
Antineoplastic AgentsDrug DesignImidazolesProtein Kinase InhibitorsQuinoxalinesTubulinTubulin ModulatorsAmidesCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorErbB ReceptorsHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAmidesAntineoplastic AgentsEGFR protein, humanErbB ReceptorsImidazolesProtein Kinase InhibitorsQuinoxalinesTubulinTubulin Modulatorsdual-target anticancer agentsEGFR kinase inhibitionmolecular docking and dynamicsROS-mediated apoptosistubulin polymerisation
Identifiers
PMID42179048
PMCPMC13202676
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