Evidence map›Paper›PMID 42178995›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Bilateral SERS-Microneedle Patch for Co-Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity.

Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao and 3 more

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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Xueqin HuangThe First Dongguan Affiliated Hospital, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan, China.
Lingzhi ChenState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, The Fifth Affiliated Hospital, College of Pharmacy, Jinan University, Guangzhou, China.
Jing XuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, The Fifth Affiliated Hospital, College of Pharmacy, Jinan University, Guangzhou, China.
Jiaqi YuThe First Dongguan Affiliated Hospital, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan, China.
Shanze ChenState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, The Fifth Affiliated Hospital, College of Pharmacy, Jinan University, Guangzhou, China.
Huaihong CaiCollege of Chemistry and Materials Science, Jinan University, Guangzhou, China.
Yanguang CongThe First Dongguan Affiliated Hospital, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan, China.
Pinghua SunState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, The Fifth Affiliated Hospital, College of Pharmacy, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0001-8963-6731
Jiang PiThe First Dongguan Affiliated Hospital, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0000-0003-4418-1248
Lang RaoInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China.ORCID https://orcid.org/0000-0001-5010-0729
Jierong ChenDepartment of Clinical Laboratory, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Junxia ZhengSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.ORCID https://orcid.org/0000-0002-1107-6284
Haibo ZhouThe First Dongguan Affiliated Hospital, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0000-0002-0098-5968

Funding

National Natural Science Foundation of China 82574360 82304438Science and Technology Projects in Guangzhou 202102070001
6 · The paper itself

Abstract

The prevalence of diabetes mellitus (DM) and tuberculosis (TB) comorbidity is constantly rising worldwide, thus there is an urgent need for a co-diagnostic method of TB-DM in the clinic. Here, we introduced a bilateral surface-enhanced Raman scattering (SERS)-microneedle (MN) patch that incorporated Au hybrid mesoporous polydopamine-coated urchin Au/Ag (U@mP@Au) for analyzing glucose in interstitial fluid (ISF) and TB biomarker (ESAT-6/CFP-10) in sputum toward the co-detection of TB-DM comorbidity. The feasibility of the bilateral SERS-MN patch was demonstrated in ex vivo artificial skin, in vivo mouse models, and trials of recruiting patients. In the clinical assessment, DM patients (N = 18) and healthy subjects (N = 3) were classified with satisfactory sensitivity (88.9%) and specificity (100%), among which one DM positive sample (P11) with TB infection was successfully identified. Results revealed the sensitivity (87.5%) and specificity (90.9%) of SERS-MN array for TB diagnosis (N = 33), which were comparable to traditional clinical methods (smear, TST, and Xpert). More importantly, three TB-positive patients (P9, P15, and P20) showed abnormally elevated glucose levels, which is highly suggestive of TB-DM complication. This integrated dual-analyte detecting platform represented a significant step toward the cooperative diagnosis of TB-DM comorbidity, facilitating the early detection of complications by clinicians.

Indexed as

Diabetes MellitusSpectrum Analysis, RamanTuberculosisAdultAnimalsComorbidityFemaleHumansMaleMiceMiddle AgedSensitivity and SpecificitySputumdiabetes mellitusmicroneedlesurface‐enhanced raman scatteringtuberculosis

Identifiers

PMID42178995
PMCPMC13335952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.