Evidence map›Paper›PMID 42178868›Full record

ArticleFEBS letters2026

TG-interacting factor 1 mediates TNF-induced Ccl2 expression in adipocytes to promote prostate cancer progression.

Kuan-Hua Huang, Hung-Wen Tsai, Yu-Pu Chu, Yu-Hao Chang, Xin-Lei Liu, Wei-Lun Tsai, Huei-Sheng Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kuan-Hua HuangDivision of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
Hung-Wen TsaiDepartment of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yu-Pu ChuDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yu-Hao ChangDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0003-4805-6620
Xin-Lei LiuDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wei-Lun TsaiDepartment of Genomic Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Huei-Sheng HuangDepartment of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-0071-7912

Funding

Chi Mei Medical Center CMNCKU111Chi Mei Medical Center CMNCKU11313National Science and Technology Council 112-2314-B-006-059National Science and Technology Council 114-2622-B-006-006-
6 · The paper itself

Abstract

Periprostatic adipose tissue secretes chemokines and lipid mediators that, particularly in the context of obesity, enhance prostate cancer cell (PCa) migration and invasion. Treating 3 T3-F442A pre-adipocytes with conditioned medium (CM) from M1-like RAW264.7 cells resulted in a significant upregulation of TG-interacting factor 1 (Tgif1) expression. Using a Tgif1 promoter reporter assay, we showed that the tumor necrosis factor (TNF) transcriptionally upregulates Tgif1 promoter activity, consistent with increased mRNA and protein expression. We also demonstrated that Tgif1 contributes to the modulation of TNF-driven Il-6 and Ccl2 cytokine mRNA expression in Tgif1-knockout and Tgif1-overexpressing 3 T3-F442A pre-adipocytes. CM from Tgif1-overexpressing cells showed a positive correlation between Tgif1 expression and PCa cell migration. We conclude that Tgif1 mediates TNF-induced Ccl2 expression in pre-adipocytes, thereby promoting PCa progression.

Indexed as

AdipocytesChemokine CCL2Homeodomain ProteinsProstatic NeoplasmsRepressor ProteinsTumor Necrosis Factor-alphaAnimalsCell Line, TumorCell MovementDisease ProgressionGene Expression Regulation, NeoplasticHumansMaleMicePromoter Regions, GeneticCcl2 protein, mouseChemokine CCL2Homeodomain ProteinsRepressor ProteinsTumor Necrosis Factor-alphaadipocytesCcl2prostate cancerTG‐interacting factor 1TNF

Identifiers

PMID42178868
PMCPMC13358431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.