ArticleMolecular microbiology2026
Regulation of the Yersinia pseudotuberculosis Type III Secretion System by the CpxAR Two-Component System.
Karen Hug, Erin Mettert, Melissa Estrada Escobar, Cristina Vargas Vazquez, David Balderas, Sarvind Tripathi, Laya Ashley, Patricia J Kiley, Victoria Auerbuch
Abstract read
In one paragraphArticle in Molecular microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Karen HugDepartment of Microbiology & Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Erin MettertDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Melissa Estrada EscobarDepartment of Microbiology & Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Cristina Vargas VazquezDepartment of Microbiology & Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
David BalderasDepartment of Microbiology & Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Sarvind TripathiDepartment of Chemistry & Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA.
Laya AshleyDepartment of Microbiology & Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Patricia J KileyDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Victoria AuerbuchDepartment of Microbiology & Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.ORCID 0000-0002-9475-4756 Funding
UCSC PREPR25GM104552 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI William T. SULLIVAN · 2013 to 2026
$3.9MUCSC Research Mentoring Internship Program: An Initiative to Increase Diversity and Inclusion in Genomics ResearchR25HG006836 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BROOKS, ANGELA NORIE, RAMON, MARINA L · 2013 to 2025
$3.7MHost iron and Yersinia pathogenesisR01AI119082 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STONE, VICTORIA AUERBUCH · 2016 to 2020
$2.5MReading the host terrain: how pathogen sensing of host environmental cues controls the outcome of bacterial infectionR01AI187307 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Victoria Auerbuch Stone · 2026 to 2026
$810kNHGRI NIH HHS R25 HG006836NIAID NIH HHS R01 AI119082NIAID NIH HHS R01 AI187307NIGMS NIH HHS R25 GM104552NIH HHS 4R25HG006836NIH HHS 5R25GM104552NIH HHS R01AI119082NIH HHS R01AI187307
6 · The paper itselfAbstract
The type III secretion system (T3SS) is a cell envelope-spanning injectisome found in many Gram-negative pathogens. Expression of the T3SS is controlled by extracellular signals such as cell envelope stress. The CpxAR two-component system negatively regulates the Yersinia pseudotuberculosis Ysc T3SS, although the mechanism remains unclear. As expected, we found that mutants with constitutive CpxR activity (∆cpxA and cpxR
Indexed as
Bacterial ProteinsGene Expression Regulation, BacterialProtein KinasesType III Secretion SystemsYersinia pseudotuberculosisGene Expression ProfilingBacterial ProteinsCpxA protein, bacteriaCpxR protein, BacteriaProtein KinasesType III Secretion Systems
Identifiers
PMID42178811
PMCPMC13353760
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