Evidence map›Paper›PMID 42178721›Full record

ArticleGut microbes2026

Altered SIgA-targeting of gut microbiota is associated with long-term dysbiosis in pediatric solid organ transplant recipients.

Kora Schulze, Imeke Goldschmidt, Anette Melk, Martin Boehne, Sabrina Woltemate, Matthias Ballmaier, Svea Kleiner, Elena Lehmann, Miriam Kramer, Marius Vital

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kora SchulzeInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
Imeke GoldschmidtDepartment of Pediatric Liver, Kidney and Metabolic Diseases, Division of Pediatric Hepatology and Liver Transplantation, Hannover Medical School, Hannover, Germany.
Anette MelkDepartment of Pediatric Liver, Kidney and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Martin BoehneDepartment of Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Sabrina WoltemateInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
Matthias BallmaierCentral Research Facility Cell Sorting, Hannover Medical School, Hannover, Germany.
Svea KleinerDepartment of Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Elena LehmannDepartment of Pediatric Liver, Kidney and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Miriam KramerInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
Marius VitalInstitute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-4185-3475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of the gut microbiota (GM) is altered in solid organ transplantation (SOT) recipients, where the degree of dysbiosis is associated with long-term survival and is believed to be influenced by immunosuppression therapy. At the interface stands secretory (S)IgA, however, little is known about its role in governing dysbiosis in the context of SOT. We performed quantitative metagenomic analyses of the GM accompanied by SIgA sequencing in 48 pediatric SOT recipients (age = 10.6 ± 4.7 y) receiving either heart (

Indexed as

BacteriaDysbiosisGastrointestinal MicrobiomeImmunoglobulin A, SecretoryOrgan TransplantationAdolescentChildChild, PreschoolFecesFemaleHeart TransplantationHumansImmunosuppression TherapyImmunosuppressive AgentsMaleMetagenomicsImmunoglobulin A, SecretoryImmunosuppressive AgentsTacrolimusIgAimmunosuppressionmetagenomicsMicrobiotasolid organ transplantation

Identifiers

PMID42178721
PMCPMC13203069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.