ArticleProtein science : a publication of the Protein Society2026
On the relationship between efficiency and cooperativity in multi-subunit molecular machines.
Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- On the relationship between efficiency and cooperativity in multi-subunit molecular machines.Protein science : a publication of the Protein Society · 2026Article
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2 authors.
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Abstract
Two key properties of machines are the extent of coordination between their moving parts and their efficiencies. Here, we analyze how the extent of coordination, as reflected in cooperativity between subunits in an oligomeric molecular machine, affects its efficiency. The efficiency is found to increase in a non-linear fashion with increasing cooperativity. In the case of a given cooperativity, efficiency increases when the allosteric constant, that is, the energy difference between the two apo states of the machine, increases or when the binding energy for the high affinity state increases but not both. These results highlight design principles that can guide strategies for increasing machine efficiency.
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