Evidence map›Paper›PMID 42178649›Full record

ReviewThe Journal of international medical research2026

Correlation between hyperuricemia and coronary artery calcification.

Zhixiong Zhong, Fuwen Zhang, Xinying Hu, Jianan He, Lu Nie

Abstract readReview
In one paragraph

Review in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhixiong ZhongDepartment of Cardiovascular Medicine, Shaoguan First People's Hospital, China.ORCID 0000-0003-3563-2756
Fuwen ZhangShaoguan University, School of Medicine, China.
Xinying HuShaoguan University, School of Medicine, China.ORCID 0009-0000-1239-2345
Jianan HeDepartment of Cardiovascular Medicine, Shaoguan First People's Hospital, China.
Lu NieShaoguan University, School of Medicine, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review aims to systematically explore the association between hyperuricemia and the degree of coronary artery calcification. We conducted a narrative review of scientific studies published over the past 5 years that examined the relationship between hyperuricemia and coronary artery calcification. The focus was on synthesizing evidence from epidemiological investigations, mechanistic studies, and clinical trials. Recent evidence confirms a significant epidemiological association between elevated serum uric acid levels and the prevalence and progression of coronary artery calcification. Mechanistic studies have identified multiple pathways through which uric acid promotes calcification, including inducing oxidative stress, causing endothelial dysfunction, triggering the phenotypic transformation of vascular smooth muscle cells into osteoblast-like cells, and fostering chronic inflammation. Hyperuricemia contributes to the development and progression of coronary artery calcification through a complex interplay of pathological mechanisms.

Indexed as

Coronary Artery DiseaseCoronary VesselsHyperuricemiaVascular CalcificationAnimalsHumansInflammationMuscle, Smooth, VascularOxidative StressUric AcidUric Acidcalcium–phosphate metabolism disordercoronary artery calcificationHyperuricemiainflammatory responseoxidative stressvascular smooth muscle cells

Identifiers

PMID42178649
PMCPMC13241020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.