Evidence map›Paper›PMID 42178587›Full record

ArticleJournal of medical case reports2026

Growing teratoma syndrome of the ovary: a case series.

Mpokigwa Kiputa, Tariq Aziz, Advera Ngaiza, Nana Nakiddu, Murali Chintagumpala, Lulu Chirande

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Mpokigwa KiputaDepartment of Paediatrics and Child Health, School of Medicine, Muhimbili University of Health and Allied Sciences, Upanga West, 9 United Nations Road, P.O. Box 65001, Dar Es Salaam, Tanzania. mpokigwakiputa@gmail.com.ORCID http://orcid.org/0000-0001-5627-6725
Tariq AzizDepartment of Radiology, Muhimbili National Hospital, Dar Es Salaam, Tanzania.
Advera NgaizaDepartment of Pathology, Muhimbili National Hospital, Dar Es Salaam, Tanzania.
Nana NakidduDepartment of Paediatrics and Child Health, School of Medicine, Muhimbili University of Health and Allied Sciences, Upanga West, 9 United Nations Road, P.O. Box 65001, Dar Es Salaam, Tanzania.
Murali ChintagumpalaTexas Children's Cancer Center, Baylor College of Medicine, Houston, TX, United States.
Lulu ChirandeDepartment of Paediatrics and Child Health, School of Medicine, Muhimbili University of Health and Allied Sciences, Upanga West, 9 United Nations Road, P.O. Box 65001, Dar Es Salaam, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowing teratoma syndrome (GTS) is a rare clinical phenomenon characterized by an enlarging tumor during or after completion of therapy for a germ cell tumor. CASE PRESENTATION: We report two Black African females, aged 10 and 12 years, with an initial diagnosis of malignant ovarian tumor with elevated alpha-fetoprotein (AFP) and B-human chorionic gonadotropin (B-HCG). After initiation of chemotherapy, the tumors progressed while the tumor markers continued to decline. Subsequent removal of the tumors showed mature teratoma with no malignant components.

conclusionGTS is often mistaken for disease progression. High index of suspicion is required when an abdominal germ cell tumor progresses on therapy with declining tumor markers.

Indexed as

Neoplasms, Germ Cell and EmbryonalOvarian NeoplasmsTeratomaalpha-FetoproteinsAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorChildChorionic Gonadotropin, beta Subunit, HumanDisease ProgressionFemaleHumansOvariectomyTreatment Outcomealpha-FetoproteinsBiomarkers, TumorChorionic Gonadotropin, beta Subunit, HumanCase seriesGerm cell tumorGrowing teratoma syndromeOvaryTumor markers

Identifiers

PMID42178587
PMCPMC13377968

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.