Evidence map›Paper›PMID 42178582›Full record

ArticleCell & bioscience2026

LBH deficiency influences the therapeutic effects of regulatory B cells through the regulation of IL-10 production via the Rap1 pathway.

Weijia Bao, Ke Hu, Yuan Qu, Yihong He, Xiaotong Zhu, Yuping Zhang, Yage Tian, Ligang Jie, Qinghong Yu

Abstract read
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In one paragraph

Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Weijia Bao *Department of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Ke Hu *Department of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Yuan QuDepartment of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Yihong HeDepartment of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Xiaotong ZhuDepartment of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Yuping ZhangDepartment of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Yage TianDepartment of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Ligang JieDepartment of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China. jieligang1976@smu.edu.cn.
Qinghong YuDepartment of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China. yuqinghong@smu.edu.cn.

Funding

National Natural Science Foundation of China 82071752National Natural Science Foundation of China 82302015National Natural Science Foundation of China 82402086National Natural Science Foundation of China 82474245Natural Science Foundation of Guangdong Province 2024A1515012856
6 · The paper itself

Abstract

Regulatory B cells (Bregs) are immune cells that affect the autoimmune response by producing interleukin (IL)-10, but the molecular mechanism affecting Breg differentiation and IL-10 production is not clear. Our study found that mice with limb bud and limb-bud and heart (LBH) gene deficiency in dextran sulfate sodium (DSS)-induced colitis showed severe colitis but exhibited an increase in Bregs in mesenteric lymph nodes and the spleen. LBH deficiency increased IL-10 production and expression of the surface molecule CD24 in B cells. Mechanistically, Ras-proximate-1 (Rap1) signaling pathway activation in LBH-deleted B cells and simultaneous inhibition of Rap 1 activation or extracellular signal-related kinase (ERK) phosphorylation reduced Breg differentiation among B cells. Furthermore, LBH deficient B cells showed a more significant therapeutic effect on DSS-induced colitis. Taken together, the results of this study revealed the mechanism by which LBH affects IL-10 production during Breg differentiation and that LBH deficiency enhanced the therapeutic efficacy of B cells for DSS-induced colitis.

Indexed as

Inflammatory bowel diseaseInterleukin-10Limb-bud and heartRas-proximate-1 pathwayRegulatory B cells

Identifiers

PMID42178582
PMCPMC13377972

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