Evidence map›Paper›PMID 42178560›Full record

ArticleCell communication and signaling : CCS2026

Neural mesenchymal-like fibroblast-derived migrasomes promote Schwann cell proliferation and migration via tenascin-C transfer during peripheral nerve regeneration.

Yongbin Ma, Qian Wang, Hang Yu, Xingwen Chen, Yue Liu, Shang Wang, Yunxia Fan, Dan Zhou, Juan Wang, Yu Feng and 2 more

Abstract read
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In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yongbin Ma *Department of Central Laboratory, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China. mayongbin2009@163.com.
Qian Wang *Department of Central Laboratory, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China.
Hang Yu *Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, P.R. China.
Xingwen ChenDepartment of Central Laboratory, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China.
Yue LiuDepartment of Central Laboratory, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China.
Shang WangTzu Chi International College of Traditional Chinese Medicine, Vancouver, BC, Canada.
Yunxia FanDepartment of Anesthesiology, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China.
Dan ZhouDepartment of Central Laboratory, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China.
Juan WangDepartment of Central Laboratory, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China.
Yu FengDepartment of Central Laboratory, Jintan Hospital, Jiangsu University, Jintan, Jiangsu, 213200, P.R. China.
Liyang DongDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212000, P.R. China. liyangdong@ujs.edu.cn.
Tao LiCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, Zhejiang, 315100, P.R. China. 1997230062@zwu.edu.cn.

Funding

"14th Five-Year Plan" High-level Talents Training Project of Changzhou 2022CZBJ101The Natural Science Foundation of Jiangsu Province BK20251848the Science and Technology Plan Project of Changzhou CJ20243001the Young Talent Development Plan of Changzhou Commission CZQM2020117
6 · The paper itself

Abstract

Peripheral nerve regeneration involves intricate intercellular communication between fibroblasts and Schwann cells (SCs). Migrasomes are recently identified extracellular vesicles generated in migrating cells that facilitate intercellular communication. In this study, we report that following peripheral nerve injury, neural mesenchymal-like fibroblasts (NMLFs) undergo extensive proliferation and expansion, with the concurrent production of migrasomes. These NMLF-derived migrasomes not only promote SC proliferation and migration but also act crucially as directional cues to guide SC migration. We demonstrate that mechanistically, NMLF migrasomes facilitate SC proliferation and migration through the transfer of tenascin-C (TNC). Collectively, our findings reveal a novel migrasome-mediated communication mechanism between NMLFs and Schwann cells, highlighting migrasomes as a promising therapeutic target for enhancing peripheral nerve regeneration.

Indexed as

Cell MovementFibroblastsNerve RegenerationPeripheral NervesSchwann CellsTenascinAnimalsCell ProliferationTenascinMigrasomeNeural mesenchymal-like fibroblastsPeripheral nerve regenerationSchwann cellsTenascin-C

Identifiers

PMID42178560
PMCPMC13377715

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.