ArticleAdvances in experimental medicine and biology2026
Behavior Prediction in Signaling Networks: Modeling of p16-Mediated Pathway.
Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Quantitative analysis of signaling networks necessitates modeling frameworks that explicitly account for both the intrinsic randomness of biochemical reactions and the pervasive uncertainty associated with incompletely characterized kinetic parameters. In this chapter, a comprehensive hierarchical Petri net model of the p16-mediated signaling pathway in higher eukaryotes is developed and examined under deterministic, purely stochastic, and fuzzy stochastic modeling paradigms. The proposed framework integrates hierarchical Petri nets with stochastic firing semantics and incorporates parameter uncertainty through fuzzy kinetic rates represented by
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