Evidence map›Paper›PMID 42178465›Full record

ArticleEJNMMI reports2026

Real-life experience in the treatment of gallbladder carcinoma by transarterial radioembolization: a multicenter retrospective study.

Thomas Dertnig, Roman Kloeckner, Lukas Mueller, Timo Alexander Auer, Arthur J A T Braat, Malte Maria Sieren, Ulf Neumann, Stefan Kasper, Leonie S Jochheim, Benedikt M Schaarschmidt

Abstract read
In one paragraph

Article in EJNMMI reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas DertnigDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45147, Essen, Germany. thomas.dertnig@uk-essen.de.ORCID http://orcid.org/0009-0009-1362-5740
Roman KloecknerInstitute of Interventional Radiology, University Hospital Schleswig-Holstein- Campus Lübeck, 23538, Lübeck, Germany.
Lukas MuellerDepartment of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Timo Alexander AuerDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353, Berlin, Germany.
Arthur J A T BraatDepartment of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands.
Malte Maria SierenInstitute of Interventional Radiology, University Hospital Schleswig-Holstein- Campus Lübeck, 23538, Lübeck, Germany.
Ulf NeumannDepartment of General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany.
Stefan KasperDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.
Leonie S JochheimDepartment of Gastroenterology and Hepatology, Essen University Hospital, Essen, Germany.
Benedikt M SchaarschmidtDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45147, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with liver metastases from gallbladder carcinoma have limited treatment options. This retrospective multicenter study evaluated overall survival, tumor control and safety after transarterial radioembolization in this rare patient group. MATERIALS AND

methodsPatients with histologically confirmed gallbladder carcinoma and liver-dominant metastatic disease treated with yttrium-90 or holmium-166 radioembolization at five tertiary centres were retrospectively identified. Baseline clinical and imaging data, details of the radioembolization procedure and follow-up imaging were collected. Tumor response was assessed locally using RECIST 1.1. Overall survival was analysed descriptively using Kaplan–Meier curves.

resultsSixteen patients (9 women, mean age 65.7 ± 5.5 years) were included; 93.8% had received prior systemic chemotherapy and 75.0% had extrahepatic metastases. At approximately 3 months, hepatic disease control was achieved in 81.8% (9/11) of patients with available imaging, whereas global disease control was 36.4% (4/11). Median overall survival was 7.1 months (95% confidence interval 1.7–12.3). The median time to hepatic progression was 115 days and the median time to global progression was 112 days. Procedure-related complications were limited to one coil dislocation, one contrast reaction and one liver abscess.

conclusionRadioembolization was feasible and well tolerated in patients with liver-dominant metastases from gallbladder carcinoma and provided intrahepatic disease control in a heavily pretreated population. Given the small sample size, these exploratory findings require confirmation in prospective studies.

Indexed as

Gallbladder carcinomaInterventional oncologyLiver metastasesRadioembolizationYttrium-90

Identifiers

PMID42178465
PMCPMC13199534

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