Evidence map›Paper›PMID 42178427›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Clinical, cognitive and neuropsychiatric correlates of personality in Wilson's disease.

Natascia De Lucia, Raffaele Lisbino, Margherita Matarazzo, Augusta Giglio, Rosa Coppola, Fabiola Di Dato, Raffaele Iorio, Gabriele Riccio, Nelson Mauro Maldonato, Antonio Terracciano and 1 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Natascia De LuciaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", via S. Pansini 5, Naples, 80131, Italy. natascia.delucia@unina.it.ORCID http://orcid.org/0000-0002-0818-0494
Raffaele LisbinoDepartment of Mental and Physical Health and Preventive Medicine, University of Campania, Naples, Italy.
Margherita MatarazzoDepartment of Translational Medical Science, Federico II University, Naples, Italy.
Augusta GiglioDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", via S. Pansini 5, Naples, 80131, Italy.
Rosa CoppolaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", via S. Pansini 5, Naples, 80131, Italy.
Fabiola Di DatoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy.
Raffaele IorioDepartment of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy.
Gabriele RiccioDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", via S. Pansini 5, Naples, 80131, Italy.
Nelson Mauro MaldonatoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", via S. Pansini 5, Naples, 80131, Italy.
Antonio TerraccianoDepartment of Geriatrics, Florida State University College of Medicine, Tallahassee, FL, USA.
Anna De RosaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", via S. Pansini 5, Naples, 80131, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWilson's disease (WD) is an autosomal recessive disorder characterized by hepatic, neurologic, or psychiatric symptoms. Compared to other recognized clinical symptoms, the personality profile of WD patients remains under-investigated. This study compared personality traits in a sample of adults with WD and healthy controls (HC). Moreover, we assessed the cognitive and affective correlates of personality within the WD group.

methodsWe enrolled 20 patients affected with genetically confirmed WD, with prevalent extrapyramidal symptoms, and 20 age and education-matched HC. Participants completed the revised Eysenck Personality Questionnaire, neuropsychological tests, and psychological questionnaires.

resultsWD patients scored significantly higher on neuroticism (Cohen's d = 1.28; Confidence Interval: 0.61-1.95) and psychoticism (Cohen's d = 0.72; Confidence Interval: 0.08-1.36) compared to HC, but no differences were observed for extraversion. Among WD patients, neuroticism correlated with global disability, trail making test, depression, and mental health status; psychoticism correlated with memory and executive functions (all r > ± 0.5).

conclusionWe observed that WD patients are characterized by high neuroticism and psychoticism, and this personality profile is related to other clinical, cognitive, and neuropsychiatric manifestations. Identification of personality traits can enhance early detection, improve monitoring, and guide targeted management strategies for individuals with WD.

Indexed as

Hepatolenticular DegenerationPersonalityAdultCognition DisordersFemaleHumansMaleMiddle AgedNeuropsychological TestsNeuroticismYoung AdultMotor diseaseNeuroticismPersonalityPsychoticismWilson’s disease

Identifiers

PMID42178427
PMCPMC13199194

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