Observational studyScientific reports2026
Association between CRP rs1800947 genotypes, dexamethasone use, postoperative CRP level and morbidity in adult cardiac surgical patients in post-hoc analysis of the observational INFLACOR cohort trial.
Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01020409 (INFLACOR), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INFLACOR (INFLA-mmation A-fter C-ardiac O-pe-R-ation) - Use of Selected Genetic Variants, Cytokines, and Physiologic Parameters in the Prognosis of Postoperative Complications in Patients Undergoing Cardiopulmonary Bypass Cardiac Surgery
Who cites it
1 citing paper in PubMed.
- Perioperative neutrophil-to-lymphocyte ratio trajectories and creatinine-defined acute kidney disease after cardiac surgery: a study using the INSPIRE database.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Postoperative inflammation contributes to organ dysfunction and complications after cardiac surgery. C-reactive protein (CRP) is a common marker of systemic inflammation. In this study, we assessed how postoperative CRP levels and their trajectories are associated with the CRP rs1800947 gene variant and perioperative dexamethasone use, and how these factors relate to postoperative morbidity. We analysed CRP levels in 484 adults who underwent cardiac surgery with cardiopulmonary bypass (CPB). CRP levels on postoperative day 1 (CRP1) were compared across the rs1800947 genotype and intraoperative dexamethasone dose: (1) none, (2) low (median 0.4 mg/kg), or (3) high (median 1.0 mg/kg). The 4-day CRP trajectories were evaluated in a subgroup of 174 patients with serial CRP measurements. The composite outcome of 30-day morbidity and mortality was analysed to reveal the association with CRP trajectories.
resultsAdjusted analysis revealed an association between the GC genotype and a 15% reduction in CRP1 levels. Dexamethasone, regardless of dose, reduced CRP1 levels by ~ 30%. Morning surgery increased CRP1 levels by 27%. Elevated preoperative CRP levels increased postoperative CRP1 levels by 19%. CRP trajectories varied by genotype and dexamethasone exposure. Patients were grouped into four trajectory types, whose associations with postoperative complications differed significantly.
conclusionsPostoperative CRP levels and trends were associated with genetic and clinical factors. Low-dose dexamethasone is as effective as high-dose dexamethasone in limiting increases in CRP1 level. The CRP patterns associated with CRP genotypes and dexamethasone use potentially represent inflammatory endotypes linked to different morbidity risks.
trial registrationThis study was registered in the US National Clinical Trial under the code NCT01020409 https://clinicaltrials.gov/ct2/show/study/NCT01020409. Registered on November 24, 2009.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.