Evidence map›Paper›PMID 42178336›Full record

ArticleScientific reports2026

VISFATIN: a novel modulator of placental endocrinology under physiological and pathological conditions-in vitro studies involving INSR, ERK1/2, and PKA signalling pathways.

Monika Dawid, Wiktoria Gieras, Tomasz Milewicz, Agnieszka Rak

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Monika DawidLaboratory of Physiology and Toxicology of Reproduction, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland. monika.dawid@doctoral.uj.edu.pl.
Wiktoria GierasLaboratory of Physiology and Toxicology of Reproduction, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland.
Tomasz MilewiczDepartment of Gynaecological Endocrinology, Faculty of Medicine, Jagiellonian University Medical College, Mkołaja Kopernika 23, 31-501, Kraków, Poland.
Agnieszka RakLaboratory of Physiology and Toxicology of Reproduction, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387, Kraków, Poland.

Funding

Jagiellonian University, Poland Research Support Module no. 446.31150.61.2022Ministry of Science and Higher Education, Poland Diamond Grant no. DI2019 0110 49
6 · The paper itself

Abstract

This study aimed to determine the in vitro effects of visfatin on selected endocrine mediators in the human placenta. Using placental BeWo cells and villous explants from normal pregnancies and those complicated by intrauterine growth restriction (IUGR), preeclampsia (PE), and gestational diabetes mellitus (GDM), we determined the effects of visfatin on 3β-hydroxysteroid dehydrogenase (3β-HSD), aromatase (CYP19), human chorionic gonadotropin (hCG), human placental lactogen (hPL), placental growth hormone (GH2) expression, and the secretion of progesterone (P

Indexed as

Antigens, CDCyclic AMP-Dependent Protein KinasesMAP Kinase Signaling SystemNicotinamide PhosphoribosyltransferasePlacentaReceptor, InsulinAromataseCell LineChorionic GonadotropinCytokinesDiabetes, GestationalFemaleHumansPregnancyProgesteroneSignal TransductionAntigens, CDAromataseChorionic GonadotropinCyclic AMP-Dependent Protein KinasesCytokinesINSR protein, humanNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanProgesteroneReceptor, InsulinAdipokinesHormone secretionPlacental explantsPregnancy pathologiesTrophoblasts

Identifiers

PMID42178336
PMCPMC13434048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.