Evidence map›Paper›PMID 42178324›Full record

ArticleScientific reports2026

A multicenter study on occult lymph node metastases in sinonasal malignancies.

Christina Sauter, Nina Wenda, Miray-Su Yilmaz Topçuoğlu, Maximilian Linxweiler, Noran Elawany, Charlotte Voigt, Marc Scheithauer, Patrick J Schuler, Johannes Zenk, Thomas K Hoffmann and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christina SauterDepartment of Otolaryngology, Augsburg University Hospital, University Hospital Augsburg, Sauerbruchstr. 6, 86179, Augsburg, Germany. christinasauter@outlook.de.
Nina WendaDepartment of Otolaryngology, Head and Neck Surgery, Helios HSK, Wiesbaden, Germany.
Miray-Su Yilmaz TopçuoğluDepartment of Otorhinolaryngology- Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Maximilian LinxweilerDepartment of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, Homburg, Germany.
Noran ElawanyDepartment of Otolaryngology, Augsburg University Hospital, University Hospital Augsburg, Sauerbruchstr. 6, 86179, Augsburg, Germany.
Charlotte VoigtDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
Marc ScheithauerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
Patrick J SchulerDepartment of Otorhinolaryngology- Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Johannes ZenkDepartment of Otolaryngology, Augsburg University Hospital, University Hospital Augsburg, Sauerbruchstr. 6, 86179, Augsburg, Germany.
Thomas K HoffmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.
Johannes DoescherDepartment of Otolaryngology, Augsburg University Hospital, University Hospital Augsburg, Sauerbruchstr. 6, 86179, Augsburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical interventions for head and neck carcinoma patients with clinically node-negative neck encompass either elective neck dissection (ND) during primary tumor excision or a wait-and-scan approach. For the rare entity of sinonasal malignancies, no standard guideline exists. This study aims to assess the prevalence of occult lymph node metastasis and evaluate the impact of elective ND on recurrence and survival. This retrospective multicenter study included patients with histologically confirmed sinonasal malignancy between 2012 and 2022. Patient-, disease-, and therapy-specific factors were systematically collected and analyzed. The therapeutic approach was based on recommendations from an interdisciplinary head and neck tumor board. A total of 438 patients with a mean age of 62 years was included. Occult metastases were observed in 8.0% of all cN0 patients assessed by objective imaging. Elective ND was performed in 25% of patients. Histologic subtype of squamous cell carcinoma (SCC) was the only pretherapeutic risk factor identified (OR 6.10; p = 0.019). Five-year disease-free survival (DFS) was significantly reduced in patients with occult lymph node metastasis (p < 0.001). This multicenter study demonstrates a comparatively low risk of occult lymph node metastases in sinonasal malignancies, but significantly reduced DFS. The low rate of occult metastases questions the necessity of systematic elective ND. The indication for elective ND should be critically assessed depending on histology.

Indexed as

Lymphatic MetastasisLymph NodesParanasal Sinus NeoplasmsAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeck DissectionNeoplasm Recurrence, LocalRetrospective StudiesElective neck dissectionHead and neck cancerOccult lymph node metastasisPatterns of failureSinonasal cancerSinonasal malignancy

Identifiers

PMID42178324
PMCPMC13199410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.