ArticleThe clinical respiratory journal2026
The Relationship Between the Cortico-Diaphragmatic Conduction Pathway and Cardiopulmonary Function in Healthy Individuals.
Article in The clinical respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsTo investigate whether there is a correlation between the parameters of cardiopulmonary function tests and corticospinal diaphragm pathway parameters in healthy individuals.
methodsSeventeen healthy adults participated in all tests. Transcranial magnetic stimulation (TMS) was employed to assess corticospinal diaphragm excitability, measuring the diaphragmatic resting motor threshold (DRMT), cortical motor evoked potential amplitude (CMEPA), and cortical motor evoked potential latency (CMEPL). Functional capacity was evaluated using the 6-min walk test (6MWT), pulmonary ventilation function was assessed via pulmonary function tests (PFT), and cardiopulmonary endurance was determined by cardiopulmonary exercise test. (CPET). The relationships between TMS-derived parameters and cardiopulmonary function indices were examined using correlation analysis and stepwise regression analysis.
resultsRegression analyses identified two key independent predictors. First, forced expiratory volume in 1 s (FEV1) was an independent predictor of DRMT. DRMT also correlated with other measures of pulmonary function and exercise capacity. Second, maximum heart rate (HR
conclusionThis study demonstrates that in healthy adults, better pulmonary function (reflected by higher FEV1) is associated with a higher DRMT and greater cardiovascular reserve (reflected by higher HR
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