Evidence map›Paper›PMID 42178184›Full record

ArticleJournal of biomedical research2026

CYP3A triggers BDE47-induced ferritinophagy and ferroptosis in spermatogenic cells through ROS-mediated m

Shuyu Xu, Wenxia Fan, Jiangxue Qian, Yuewen He, Chunjin Li, Chao Chen, Li Wang, Yongquan Yu, Chao Wang, Shoulin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuyu XuState Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Wenxia FanKey Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Jiangxue QianKey Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Yuewen HeState Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Chunjin LiState Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Chao ChenKey Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Li WangKey Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Yongquan YuKey Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Chao WangKey Lab of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211116, China.
Shoulin WangState Key Lab of Reproductive Medicine and Offspring Health, Institute of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 211116, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 CYP3A (CYP3A) is among the most abundant hepatic cytochrome P450 subfamilies and also mediates the metabolism and toxicity of xenobiotics. Previous studies have reported that CYP3A is also expressed in the testis; however, its role and molecular mechanism in mediating male reproductive damage remain unclear. In this study, through

Indexed as

2,2',4,4'-tetrabromodiphenyl ethercytochrome P450 3Aferritinophagymale reproductive damageN6-methyladenosinereactive oxygen species

Identifiers

PMID42178184
PMCPMC13438320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.