Evidence map›Paper›PMID 42178172›Full record

ArticleThe Journal of physiology2026

NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells.

David C H Benton, Alan D Robertson, Matthew Caldwell, Yuriy Pankratov, Lema Imam, Trevor G Smart, Gareth Morris, Guy W J Moss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David C H BentonDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Alan D RobertsonDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Matthew CaldwellDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID https://orcid.org/0000-0002-9578-1676
Yuriy PankratovDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Lema ImamDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Trevor G SmartDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID https://orcid.org/0000-0002-9089-5375
Gareth MorrisDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID https://orcid.org/0000-0003-2469-5102
Guy W J MossDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.ORCID https://orcid.org/0000-0002-0192-6353

Funding

Biotechnology and Biological Sciences Research Council BB/D01817X/1Epilepsy Research Institute UK F2102 MorrisMedical Research Council PhD Studentship RobertsonRoyal Society RGS∖R2∖222326
6 · The paper itself

Abstract

Presynaptic receptors are important regulators of CNS activity. We have examined presynaptic receptor populations using a vibrodissociated rat cerebellar Purkinje cell preparation. In this preparation, NMDA receptor immunoreactivity co-localized with antibody staining for the presynaptic marker synaptophysin. The application of NMDA increased the frequency of both inhibitory and excitatory synaptic currents, an effect that was blocked by the addition of 1 mM Mg

Indexed as

Nerve FibersPresynaptic TerminalsPurkinje CellsReceptors, GlycineReceptors, N-Methyl-D-AspartateAnimalsCerebellumExcitatory Postsynaptic PotentialsGlycineMaleRatsRats, Sprague-DawleyGlycineReceptors, GlycineReceptors, N-Methyl-D-Aspartateclimbing fibreglycineNMDApresynaptic

Identifiers

PMID42178172
PMCPMC13267686

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.