ArticleMetabolomics : Official journal of the Metabolomic Society2026
Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.
Article in Metabolomics : Official journal of the Metabolomic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThe two-way relationship between metabolites and insomnia is not yet fully understood.
objectiveWe investigated the bidirectional relationship between metabolites and insomnia using human genome-wide association study and mouse models to identify potential biomarkers.
methodsWe analyzed data from two large genome-wide association studies: one on insomnia (336,965 participants) and one on metabolites (7,824 participants). Genetic variants related to metabolites and insomnia were examined. In the animal study, 12 mice were divided into control and chronic sleep deprivation groups (n = 6 each). After 32 days, blood and fecal metabolites were analyzed.
resultsHigher oleate levels were linked to lower insomnia risk (β: -5.99, p = 0.01), but insomnia did not alter oleate levels. Insomnia increased glucose (β: 0.18, p = 0.002), mannose (β: 0.11, p = 0.02), and influenced six lipids and four amino acids. In mice, sleep deprivation lowered corticosterone (p = 0.03), raised glucose and mannose (p = 0.001), and reduced blood (p = 0.007) and fecal oleate (p = 0.05). Fecal 4-aminobutyric acid also decreased (p = 0.01).
conclusionsInsomnia and metabolites exhibited a bidirectional relationship, with notable metabolic and hormonal changes in the animal model. Improving sleep hygiene and regular assessments may help mitigate insomnia-related metabolic disruptions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.