ArticlePlant communications2026
A positive feedback loop between NPR1 and SOG1 reinforces genotoxic tolerance in Arabidopsis.
Article in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cellular functions and viability of living organisms are constantly challenged by endogenous and environmental agents that induce DNA damage. In plants, DNA-damaging agents, such as salicylic acid (SA), and the double-strand-break-inducing antibiotic Zeocin, trigger the DNA damage response, thereby promoting genotoxic tolerance. We found that the SA-responsive gene NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) and the DNA-damage-responsive gene SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) are both essential for genotoxic tolerance. Mutants lacking either NPR1 or SOG1 exhibit reduced tolerance to genotoxic stress. Furthermore, NPR1 and SOG1 form a positive feedback loop at the transcriptional level, thereby amplifying genotoxic stress responses. Additionally, NPR1 and SOG1 physically interact and co-occupy the NAC085 promoter, synergistically activating its expression and consequently enhancing genotoxic tolerance. Genetic analysis revealed that NAC085 acts downstream of NPR1 and SOG1 to control genotoxic tolerance. Taken together, our results demonstrate that a positive feedback loop between NPR1 and SOG1 promotes NAC085 expression, thereby enhancing genotoxic tolerance and safeguarding genome integrity in plants.
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