Evidence map›Paper›PMID 42177557›Full record

ArticleCell communication and signaling : CCS2026

Melatonin attenuates Mycoplasma pneumoniae-Induced Inflammation and barrier dysfunction by CXCL10/TLR4/STAT1 axis.

Chun-Yi Lee, Tsung-Hua Wu, Meei-Ling Sheu, Wen-Hsuan Chiang, Hung-Chuan Pan, Yu-Ping Fang, Yi-Ching Tsai, Chia-Yun Tsai, De-Wei Lai

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Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chun-Yi LeeDepartment of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
Tsung-Hua WuGraduate Institute of Chinese Medicine and Drug Development, National Chung Hsing University, Taichung, Taiwan.
Meei-Ling SheuInstitute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
Wen-Hsuan ChiangDepartment of Chemical Engineering, i-Center for Advanced Science and Technology (iCAST), National Chung Hsing University, Taichung, Taiwan.
Hung-Chuan PanDepartment of Medical Research, Taichung Veterans General Hospital, Rm. 320, 3F, No. 1650, Sec. 4, Taiwan Blvd., Xitun Dist, Taichung, 407219, Taiwan.
Yu-Ping FangDepartment of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
Yi-Ching TsaiPrecision gene and cell center, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
Chia-Yun TsaiDepartment of Medical Research, Taichung Veterans General Hospital, Rm. 320, 3F, No. 1650, Sec. 4, Taiwan Blvd., Xitun Dist, Taichung, 407219, Taiwan.
De-Wei LaiDepartment of Medical Research, Taichung Veterans General Hospital, Rm. 320, 3F, No. 1650, Sec. 4, Taiwan Blvd., Xitun Dist, Taichung, 407219, Taiwan. deweilai123@gmail.com.

Funding

Chang Bing Show Chwan Memorial Hospital IRD-110006National Science and Technology Council NSTC 114-2314-B-075A-009
6 · The paper itself

Abstract

Mycoplasma pneumoniae (Mp) is a major pathogen of community-acquired pneumonia increasingly resistant to macrolides. Mp infection provokes oxidative stress, disrupts epithelial integrity, and skews T helper (Th) cell balance through CARDS toxin-mediated immune dysregulation. Here, we investigated the protective effects of melatonin, a pleiotropic hormone with antioxidant and immunomodulatory functions, in patients and a murine model of Mp pneumonia. Mp infection perturbed the local Th1/Th2/Th17 balance, accompanied by ROS accumulation, CXCL10-induced TLR4/STAT1 activation, and loss of ZO1-dependent tight junctions. Melatonin administration suppressed ROS production, restored epithelial barrier integrity, and rebalanced Th responses within the airway microenvironment. Mechanistically, melatonin inhibited CXCL10-TLR4/STAT1 signaling, with TLR4 residue A366 identified as a key regulatory site. These findings reveal that melatonin alleviates Mp-induced airway injury by maintaining immune and epithelial homeostasis, highlighting its potential as an adjunctive therapy for macrolide-resistant Mp pneumonia.

Indexed as

Chemokine CXCL10InflammationMelatoninMycoplasma pneumoniaePneumonia, MycoplasmaSignal TransductionSTAT1 Transcription FactorToll-Like Receptor 4AnimalsHumansMiceMice, Inbred C57BLChemokine CXCL10MelatoninSTAT1 Transcription FactorToll-Like Receptor 4Epithelial barrierMelatoninMycoplasma pneumoniaeOxidative stressSTAT1T helper cellsTLR4

Identifiers

PMID42177557
PMCPMC13374074

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.