ArticleBiomedical engineering online2026
Asymmetric tripolar nerve cuff electrode designs for optimizing anodal block of myelinated fibers.
Article in Biomedical engineering online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeAnodal block is a common mechanism used to generate unidirectional activation of myelinated nerve fibers. However, nerve block is often inconsistent and difficult to achieve. In this study, we used a computational model to investigate electrode cuff designs that can be exploited to enhance anodal block.
methodsAsymmetric bipolar and tripolar nerve cuff electrodes were initially tested and validated in a rodent sciatic nerve model. A finite element model was implemented, with physical dimensions approximating a rat sciatic nerve implanted with a flat-interface nerve electrode. The McIntyre-Richardson-Grill model was used to predict the activation, block, and reactivation thresholds of myelinated fibers (diameter = 5.7 to 16 μm) as the stimulation amplitude was increased. In vivo experiments were performed using identical nerve cuff electrodes. The asymmetric electrode designs were subsequently investigated using a human-sized model of a nerve implanted with a cylindrical cuff electrode. Key design parameters included the electrode edge length (EEL), anodic contact width, inter-electrode distance, and current division between primary and secondary anodes.
resultsThe rodent model reproduced blocking properties in both computational and in vivo studies, where maximum anodic block reached 88% and 75% of activated fibers, respectively. Simulations involving the human nerve model identified two critical design parameters that can markedly enhance anodal block. An optimal distal EEL (≤ 1 mm) enhanced the performance of bipolar stimulation (anodic block = 91%), whereas, optimizing the current ratio between the primary:secondary anodes (e.g., 6:4) enhanced nerve block in asymmetric tripolar electrodes (anodic block = 90%).
conclusionThis study presents a set of instructions for optimizing the anodal blocking properties of nerve cuff electrodes, where an asymmetric tripolar design with variable anodic current offers a novel method that can adjust for variability at the nerve electrode interface.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.