ArticleBMC pediatrics2026
Liver transplantation for Type I Abernethy malformation with liver tumors in children: a report of two cases with contrasting portal vein reconstruction strategies.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundType I Abernethy malformation is a rare congenital portosystemic shunt with an absent intrahepatic portal vein (PV). It often presents with liver tumors or metabolic disorders. Liver transplantation (LT) is the only definitive treatment, but it poses unique technical challenges due to the absent native PV. Detailed surgical guidance for variable anatomies remains scarce. CASE PRESENTATION: We report two children with Type I Abernethy malformation who underwent LT in 2023. Both presented with benign liver tumors, hyperammonemia and abnormal liver function. Case 1 (2.5 y/m) received a deceased-donor left-lobe LT. Owing to insufficient PV length, a deceased-donor iliac vein graft was used for PV reconstruction. Case 2 (5.7 y/f) underwent living-donor left-lateral-sector LT with direct anastomosis of the donor left PV to the recipient's shunt vessel. Graft-to-recipient weight ratios (GRWR) were 2.29% and 1.45%, respectively.
resultsBoth transplant procedures were successful. Postoperative liver function and ammonia normalized. Case 2 developed hepatic venous outflow obstruction (HVOO) postoperatively, which was successfully managed with balloon angioplasty on POD 24. At 18-month follow-up, both patients were alive with good graft function, without tumor recurrence or metabolic abnormalities. To our knowledge, this is among the few reports with 18-month follow-up for pediatric patients with this disease after LT using these techniques.
conclusionThis report offers a practical and anatomy-based surgical framework for PV reconstruction in pediatric Type I Abernethy malformation: direct anastomosis when an adequate shunt vessel is present, or interposition grafting (e.g., with iliac vein) when the native portal stump is absent. These contrasting strategies achieved good early outcomes at 18 months, suggesting that LT can be a curative option for this challenging anomaly. These observations are primarily hypothesis-generating. Validation will require larger, multicenter cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.