Evidence map›Paper›PMID 42177434›Full record

ArticleBMC psychiatry2026

A nomogram model to predict the risk for etomidate use disorder with antisocial personality disorder.

Juan Le, Xingmin Wang, Ying Tang, Xinxin Chen, Qiuping Huang, Jingyue Hao, Lishun Zhao, Hongxian Shen, Zhenjiang Liao

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Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Juan Le *Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Xingmin Wang *Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Ying TangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Xinxin ChenDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Qiuping HuangDepartment of Psychology, School of Humanities and Management, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Jingyue HaoDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Lishun ZhaoDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China.
Hongxian Shen *Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China. shenhx2018@csu.edu.cn.
Zhenjiang Liao *Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha, Hunan, 410011, China. lzjcsair@163.com.

Funding

National Key Research and Development Program of China 2023YFC3304205Science and Technology Innovation 2030 "Brain science and brain-like research" Major Project of China 2021ZD0202100
6 · The paper itself

Abstract

backgroundThe co-occurrence of etomidate use disorder (EUD) and antisocial personality disorder (ASPD) poses significant challenges in clinical assessment and management. This study aims to develop a predictive model to estimate the risk of ASPD in EUD patients.

methodsMale patients with EUD were recruited from a drug rehabilitation center between March and December 2024. Behavioral, health, psychological, and sociodemographic variables were collected, and diagnoses of ASPD were established using the Mini-International Neuropsychiatric Interview (MINI). The baseline variables were screened to identify potential predictors associated with EUD co-occurring with ASPD, via least absolute shrinkage and selection operator (LASSO) regression and Boruta algorithm. A predictive nomogram model was constructed based on multivariate logistic regression analysis. The performance of the predictive model was comprehensively evaluated through the ROC curve and calibration curve. Internal validation was performed using the Bootstrap method.

resultsA total of 122 patients with EUD were included in the analysis, of whom 60 (49.2%) presented with ASPD. The final predictive model incorporated five variables: Craving (OR = 1.52; 95% CI: 1.08-2.15), Attentional impulsiveness (OR = 1.06; 95% CI: 1.03-1.09), Physical Aggression (OR = 1.04; 95% CI: 1.02-1.07), Trauma (OR = 3.08; 95% CI: 1.12-8.48), and Crime (OR = 3.48; 95% CI: 1.40-8.67). The ROC curve indicated AUC of 0.840 (p < 0.001, 95% CI: 0.770-0.909), and calibration curves indicated excellent agreement between predicted and observed outcomes in predicting EUD with comorbid ASPD.

conclusionsWe have successfully developed, evaluated and interpreted a nomogram model for predicting the co-occurrence of EUD and ASPD, which demonstrates favorable predictive performance and clinical utility. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Antisocial Personality DisorderEtomidateNomogramsSubstance-Related DisordersAdultHumansMalePrediction AlgorithmsEtomidateAntisocial personality disorder (ASPD)Drug cravingEtomidate use disorder (EUD)LASSO logistic regressionNomogram modelTraumatic experiences

Identifiers

PMID42177434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.