Evidence map›Paper›PMID 42177421›Full record

Observational studyBMC infectious diseases2026

Validation of ICD-10-CM diagnosis codes for identifying COVID-19 cases using administrative claims data in Taiwan.

Wei-Lun Chang, Chia-Ling Wu, Cheng-Hsun Chiu, Yu-Tung Huang

Abstract readValidation StudyObservational Study
In one paragraph

Observational study in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei-Lun ChangCenter for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Chia-Ling WuCenter for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Cheng-Hsun ChiuDivision of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Yu-Tung HuangNational Center for Geriatrics and Welfare Research, National Health Research Institutes, No. 95-1, Xuefu Rd., Huwei Township, Yunlin County, 632007, Taiwan. anton.huang@gmail.com.

Funding

Chang Gung Medical Foundation, Taiwan CGRPG3Q0021
6 · The paper itself

Abstract

backgroundAccurate identification of COVID-19 cases is essential for real-world studies. This study assessed the validity of ICD-10-CM code U07.1 for identifying COVID-19 cases in administrative claims data in Taiwan.

methodsThis observational validation study linked National Health Insurance claims with laboratory-confirmed SARS-CoV-2 RT-PCR results from a multi-institutional database. We included 127,300 outpatient, emergency, and inpatient encounters from 2022. Positive and negative predictive values (PPV, NPV), sensitivity, and specificity were calculated using RT-PCR results as the reference standard, with stratified analyses conducted by clinical setting, time period, patient demographics, and hospital level.

resultsOverall, the U07.1 code demonstrated high PPV (95.3%) and specificity (99.5%), but moderate NPV (77.9%) and low sensitivity (26.6%). While PPVs remained consistently high across all clinical settings (> 91%), NPVs varied significantly, being lowest in outpatient visits (41.3%). Temporally, NPV and sensitivity were lowest during April-June 2022 (57.7% and 14.9%, respectively), coinciding with the peak outbreak and the transition toward antigen-based diagnostic policies. Sensitivity was markedly higher among inpatients (84.4%) and older adults aged ≥ 80 years (60.5%) compared to younger populations.

conclusionICD-10-CM U07.1 is a highly reliable marker for identifying confirmed COVID-19 cases in Taiwan's claims data. However, the low overall sensitivity and substantial variability in NPV suggest significant under-capture of mild infections, particularly in outpatient settings. Researchers should exercise caution when using this code to estimate total disease burden or when defining code-negative control cohorts.

Indexed as

COVID-19International Classification of DiseasesAdolescentAdultAgedAged, 80 and overDatabases, FactualFemaleHumansMaleMiddle AgedSARS-CoV-2Sensitivity and SpecificityTaiwanYoung AdultAdministrative claims dataCOVID-19ICD-10-CMValidation

Identifiers

PMID42177421
PMCPMC13383511

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.