Evidence map›Paper›PMID 42177404›Full record

Observational studyBMC neurology2026

Deep medullary vein drainage and unfavorable outcomes in stroke patients after endovascular therapy: a retrospective study.

Jiating Wei, Tao Lu, Siyu Li, Jianle Li, Yuhua Fan, Jinsheng Zeng

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jiating Wei *Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, Guangdong, 510080, People's Republic of China.
Tao Lu *Department of Neurology, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, 545001, People's Republic of China.
Siyu LiDepartment of Neurology and Stroke Center, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, 545027, People's Republic of China.
Jianle LiDepartment of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, Guangdong, 510080, People's Republic of China.
Yuhua FanDepartment of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, Guangdong, 510080, People's Republic of China.
Jinsheng ZengDepartment of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, Guangdong, 510080, People's Republic of China. zengjsh@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-4280-0439

Funding

Guangdong Province International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases 2020A0505020004Guangdong Provincial Clinical Research Center for Neurological Diseases 2020B1111170002Guangzhou Major Difficult and Rare Diseases Project 2024MDRD02National Distinguished Physicians C2250501National Natural Science Foundation of China 82130035National Natural Science Foundation of China 82360239
6 · The paper itself

Abstract

backgroundIschemic stroke due to middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion often involves deep white matter, which drains through deep medullary veins (DMVs). Whether disruption of the DMVs drainage contributes to unfavorable outcomes following endovascular thrombectomy (EVT) remains unknown. This study aimed to investigate the association between DMVs continuity and post-EVT prognosis.

methodsIn this retrospective observational study from two stroke centers, we included stroke patients due to MCA or ICA occlusion who underwent EVT with successful recanalization between January 2023 and December 2024. The modified Rankin Scale (mRS) was recorded at 90 days. DMVs continuity was assessed on susceptibility weighted imaging (SWI) after EVT. Clinical data were analyzed using multivariable logistic regression and receiver operating characteristic (ROC) curves.

resultsA total of 61 patients was included (mean age: 65.4 ± 12.2 years; 63.9% male). Thirty patients (49.2%) achieved unfavorable outcomes (mRS 2-6). Compared to the favorable group, ipsilateral DMVs discontinuity was more frequent in the unfavorable group (70.0% vs. 41.9%, P = 0.040). DMV discontinuity remained independently associated with unfavorable outcomes post-EVT after adjusting for confounders (aOR = 3.23, 95% CI: 1.12-9.30, P = 0.030). ROC curve analysis indicated that the combined model of DMVs continuity status, baseline NIHSS score, and arterial collateral status showed good predictive value for prognosis post-EVT (AUC = 0.81, sensitivity = 73.3%, specificity = 80.6%).

conclusionsImpaired DMVs drainage is associated with unfavorable outcomes after EVT in ischemic stroke patients with MCA or ICA occlusion.

Indexed as

Cerebral VeinsEndovascular ProceduresInfarction, Middle Cerebral ArteryIschemic StrokeStrokeAgedFemaleHumansMaleMiddle AgedRetrospective StudiesThrombectomyTreatment OutcomeEndovascular therapyFutile recanalizationIschemic strokeVein drainage

Identifiers

PMID42177404
PMCPMC13374219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.