Evidence map›Paper›PMID 42177356›Full record

ArticleAbdominal radiology (New York)2026

MRI T1 signal intensity ratios correlate with fibrosis in recurrent acute and chronic pancreatitis.

Aida A Metri, Mahya Faghih, Elizabeth Thompson, Michael Noë, Rifat Mannan, Rita Kalyani, Elham Afghani, Venkata S Akshintala, Daniel Warren, Niraj M Desai and 7 more

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Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

17 authors.

Aida A MetriDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. aida.a.metri@medstar.net.
Mahya FaghihDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Elizabeth ThompsonBloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael NoëSidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Rifat MannanDivision of Thoracic Surgery, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.
Rita KalyaniDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Elham AfghaniDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Venkata S AkshintalaDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Daniel WarrenDivision of Transplant Surgery, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Niraj M DesaiDivision of Transplant Surgery, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Zhaoli SunDivision of Transplant Surgery, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Christi WalshDivision of Surgical Oncology, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Martin MakaryDivision of Surgical Oncology, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Ralph HrubanSidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Jin HeDivision of Surgical Oncology, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Vikesh K SinghDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Atif ZaheerRussell H. Morgan Department of Radiology and Radiological Sciences, and Pancreatitis Center, Division of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA. azaheer1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeT1 signal intensity ratio (SIR) on MRI has not been rigorously evaluated as a noninvasive method to detect pancreatic fibrosis in patients undergoing surgery for recurrent acute (RAP) and chronic pancreatitis (CP). The aim of our study was to evaluate the association between histologic fibrosis score (FS) and T1 SIR and contrast enhancement of the pancreas on MRI among patients with RAP and CP undergoing total pancreatectomy with islet autotransplantation (TPIAT).

methodsPatients who underwent MRI < 6 months before TPIAT between 2011 and 2023 were classified into 3 groups: definite CP (n = 23) and indeterminate CP (n = 11) by M-ANNHEIM criteria; and RAP defined as ≥ 2 episodes of imaging-documented acute pancreatitis (n = 22). The perilobular and intralobular fibrosis of each surgical biopsy was scored from 0 to 6. The FS was the sum of perilobular and intralobular fibrosis (0-12). We measured the T1 signal intensity of the pancreas and reference organs using pre-contrast T1-weighted fat-saturated (T1WFS) sequences to obtain the T1 SIR. We also measured the T1 signal intensity of the pancreas in the pre-contrast, arterial, venous, and delayed phases.

resultsA total of 56 patients were included. The median FS was 6.25 (range 0-12). Pancreas-to-spleen T1 SIR (p = 0.004) and pancreas-to-paraspinal T1 SIR (p = 0.03) were significantly associated with pancreatic fibrosis after adjusting for age, BMI, exocrine insufficiency, fat fraction, diabetes mellitus, and clinical diagnosis. Analysis of the enhancement curves showed that the venous phase of T1 signal intensity can differentiate between indeterminate CP, RAP and definite CP (p < 0.004 for all).

conclusionBoth the T1 SIR of the pancreas-to-spleen and pancreas-to-paraspinal muscle show an independent association with fibrosis. T1 SIR demonstrates a significant association with histologically quantified pancreatic fibrosis and may serve as a promising noninvasive imaging biomarker pending further validation.

Indexed as

Contrast-enhanced T1-weighted image phasesFat fractionTotal pancreatectomy with islet autotransplantation

Identifiers

PMID42177356

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