Evidence map›Paper›PMID 42177349›Full record

ArticleDrug delivery and translational research2026

Low dose intranasal nestorone self-emulsifying drug delivery system promotes neuroprotection in experimental stroke through modulation of glial cells.

Sara Meirinho, Susana Alves Ferreira, Catarina Diniz, Gilberto Alves, Shimin Zhang, Narender Kumar, Regine Sitruk-Ware, Gaohong Di, Manuel Navarro-Oviedo, Jesús M Pradillo and 3 more

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sara MeirinhoDepartment of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal. sara.meirinho@fcsaude.ubi.pt.
Susana Alves FerreiraDepartment of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal.
Catarina DinizDepartment of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal.
Gilberto AlvesDepartment of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal.
Shimin ZhangPopulation Council, Centre for Biomedical Research, 1230 York Avenue, New York, NY, 10065, USA.
Narender KumarPopulation Council, Centre for Biomedical Research, 1230 York Avenue, New York, NY, 10065, USA.
Regine Sitruk-WarePopulation Council, Centre for Biomedical Research, 1230 York Avenue, New York, NY, 10065, USA.
Gaohong DiPharmacology and Toxicology Department, Institute of Neurochemical Research, Faculty of Medicine, Complutense University of Madrid, Pl. de Ramon y Cajal, s/n, Moncloa, Aravaca, Madrid, 28040, Spain.
Manuel Navarro-OviedoPharmacology and Toxicology Department, Institute of Neurochemical Research, Faculty of Medicine, Complutense University of Madrid, Pl. de Ramon y Cajal, s/n, Moncloa, Aravaca, Madrid, 28040, Spain.
Jesús M PradilloPharmacology and Toxicology Department, Institute of Neurochemical Research, Faculty of Medicine, Complutense University of Madrid, Pl. de Ramon y Cajal, s/n, Moncloa, Aravaca, Madrid, 28040, Spain.
Ignacio LizasoainPharmacology and Toxicology Department, Institute of Neurochemical Research, Faculty of Medicine, Complutense University of Madrid, Pl. de Ramon y Cajal, s/n, Moncloa, Aravaca, Madrid, 28040, Spain.
Graça BaltazarDepartment of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal.
Adriana O SantosDepartment of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Av. Infante D. Henrique, Covilhã, 6200-506, Portugal. asantos@fcsaude.ubi.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a leading cause of disability worldwide, with current therapies mainly focused on clot fibrinolysis rather than neuroprotection. Nestorone

Indexed as

Glial cellsIntranasalIschemic strokeNanoemulsionNestoroneSMEDDS

Identifiers

PMID42177349

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.