ArticleCommunications biology2026
Melatonin attenuates reproductive toxicity of prothioconazole and its metabolite via spermatogenesis and oxidative stress.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Current Advances in Cetacean Semen Cryopreservation and Their Application to Yangtze Finless Porpoise Conservation.Animals : an open access journal from MDPI · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Prothioconazole (PTC), a widely used triazole fungicide, and its metabolite, prothioconazole-desthio (dPTC), have been frequently detected in environmental matrices, raising significant concerns regarding their potential adverse effects on mammalian reproductive health. While melatonin has demonstrated protective properties across multiple physiological systems, its efficacy in mitigating PTC- and dPTC-induced reproductive toxicity remains poorly understood. This study investigated the reproductive effects of PTC and dPTC in male mice and evaluated the potential protective effects of melatonin. PTC and dPTC exposure induced reproductive dysfunction, characterized by reduced sperm counts, disrupted spermatogenesis, altered HPG axis hormone secretion, elevated oxidative stress, and compromised BTB integrity. Melatonin co-treatment significantly attenuated these adverse effects, restoring sperm parameters, normalizing HPG axis function, mitigating oxidative stress, and preserving BTB integrity, possibly via the modulation of the MAPK/ERK signaling pathway. These findings underscore the potential reproductive toxicity of PTC/dPTC and propose melatonin as a promising therapeutic approach to alleviate the adverse reproductive impacts induced by triazole fungicides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.