Evidence map›Paper›PMID 42177314›Full record

ArticleScientific reports2026

Free water, occipital volume and changes in depressive symptoms in the LifeAfter90 study.

Alexander Ivan B Posis, Ruijia Chen, Hilary L Colbeth, Molly R LaPoint, Kristen M George, Paola Gilsanz, M Maria Glymour, Pauline Maillard, Yonas Tesfagabr Abraham, María M Corrada and 1 more

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Alexander Ivan B PosisDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA. abposis@health.ucdavis.edu.
Ruijia ChenDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Hilary L ColbethDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.
Molly R LaPointKaiser Permanente Northern California Division of Research, Pleasanton, CA, USA.
Kristen M GeorgeDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.
Paola GilsanzKaiser Permanente Northern California Division of Research, Pleasanton, CA, USA.
M Maria GlymourDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Pauline MaillardDepartment of Neurology, University of California, Davis, Davis, CA, USA.
Yonas Tesfagabr AbrahamDepartment of Neurology, University of California, Davis, Davis, CA, USA.
María M CorradaDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Rachel A WhitmerDepartment of Public Health Sciences, University of California, Davis, Medical Sciences 1-C, One Shield's Ave, Davis, CA, 95616, USA.

Funding

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldR01AG056519 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Maria Corrada, Paola Gilsanz · 2022 to 2026
$25.8M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
NIA NIH HHS P30 AG072972NIA NIH HHS P30AG072972NIA NIH HHS R01 AG056519NIA NIH HHS R01AG056519
6 · The paper itself

Abstract

Though depression impacts over 10% of the oldest-old, the contribution of brain health on changes in depression is unknown. This study included 225 participants from LifeAfter90 with magnetic resonance imaging, amyloid positron emission tomography (PET), and repeated Geriatric Depression Scale (GDS) data. We fit linear mixed-effects models for associations of neuroimaging markers with depressive symptom change adjusted for age, gender, race and ethnicity, and education. At baseline, average GDS scores were 2.6 (SD = 2.3) out of 15 possible points, average age was 93.3 (SD = 2.3) years, 56% female, and 22% Black, 25% Asian, 18% Hispanic/Latino, 28% Non-Hispanic White, and 7% as Multiracial/other. Greater baseline occipital volume was associated with slower GDS increase (β = - 0.29; 95% CI - 0.54, - 0.05). Greater baseline free water was associated with faster GDS increase (β = 0.31; 95% CI 0.05, 0.57). Estimates for other neuroimaging biomarkers leaned towards slower, but non-significant, increases in GDS. Estimates were not in the expected direction for amyloid PET and null for frontal cortex volume. Our findings suggest that lower cortical volume and greater white matter injury is associated with increases in depressive symptoms among the oldest old, even for those with low levels of baseline depressive symptoms.

Indexed as

DepressionOccipital LobeAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingPositron-Emission TomographyDepressionNeuroimagingOlder adultsOldest-oldProspective cohort

Identifiers

PMID42177314
PMCPMC13421447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.