Evidence map›Paper›PMID 42177276›Full record

ArticleScientific reports2026

The implications of TMSB4X in TIM3 hypermethylation and CD8

Yiming Yang, Zujun Qin, Xin Liu, Huimin Yang, Xiaolin Wang, Chao Mai, Shunhai Jian, Qiqi Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiming Yang *Department of Pathology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, 637000, Sichuan, China.
Zujun Qin *Department of Pathology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, 637000, Sichuan, China.
Xin LiuDepartment of Pathology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, 637000, Sichuan, China.
Huimin YangDepartment of Pathology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, 637000, Sichuan, China.
Xiaolin WangDepartment of Pathology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, 637000, Sichuan, China.
Chao MaiDepartment of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Shunhai JianDepartment of Pathology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, 637000, Sichuan, China.
Qiqi ZhuDepartment of Pathology, Affiliated Hospital of North Sichuan Medical College, No. 1 Maoyuan Nan road, Nanchong, 637000, Sichuan, China. 359059927@qq.com.

Funding

Scientific Research and Development Fund Project, North Sichuan Medical College CBY23-QNA35Scientific Research Startup Foundation for Doctor, North Sichuan Medical College CBY23-QDA10Sichuan Science and Technology Program 2025ZNSFSC1697
6 · The paper itself

Abstract

Epigenetic modifications of immune checkpoints (IC) are crucial for immune checkpoint blockade (ICB) efficacy. TIM3 accelerates CD8

Indexed as

CD8-Positive T-LymphocytesDNA MethylationHepatitis A Virus Cellular Receptor 2Lymphoma, Large B-Cell, DiffuseMembrane ProteinsEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansPrognosisT-Cell ExhaustionTumor MicroenvironmentHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Membrane ProteinsClinicopathological analysisDiffuse large B-cell lymphomaDNA methylationImmune checkpointPrognosisSingle-cell RNA sequencing

Identifiers

PMID42177276
PMCPMC13421516

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.