Evidence map›Paper›PMID 42177200›Full record

ArticleNPJ vaccines2026

Heterologous vaccination with a next-generation vaccinia virus and Ad26 induces Ebola-specific immunity in macaques.

Aneesh Vijayan, Tamara Cooper, Marijn van der Neut Kolfschoten, Gary Heinemann, Mirjam Van Kampen, Satish Boedhoe, Harry van Diepen, Jan Serroyen, John Hayball, Leanne Hobbs and 4 more

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Article in NPJ vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aneesh VijayanJohnson & Johnson, Leiden, The Netherlands. aneesh.vijayan@gmail.com.
Tamara CooperExperimental Therapeutics Laboratory, Clinical and Health Sciences Unit, University of South Australia, Adelaide, SA, Australia.
Marijn van der Neut KolfschotenJohnson & Johnson, Leiden, The Netherlands.
Gary HeinemannExperimental Therapeutics Laboratory, Clinical and Health Sciences Unit, University of South Australia, Adelaide, SA, Australia.
Mirjam Van KampenJohnson & Johnson, Leiden, The Netherlands.
Satish BoedhoeJohnson & Johnson, Leiden, The Netherlands.
Harry van DiepenJohnson & Johnson, Leiden, The Netherlands.
Jan SerroyenJohnson & Johnson, Leiden, The Netherlands.
John HayballExperimental Therapeutics Laboratory, Clinical and Health Sciences Unit, University of South Australia, Adelaide, SA, Australia.
Leanne HobbsSementis Ltd. Hackney, Adelaide, SA, Australia.
Anne CollinsSementis Ltd. Hackney, Adelaide, SA, Australia.
Jerome CustersJohnson & Johnson, Leiden, The Netherlands.
Roland ZahnJohnson & Johnson, Leiden, The Netherlands. rzahn@its.jnj.com.
Ronald VogelsJohnson & Johnson, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different ways of combining virus vector-based vaccines can impact the effectiveness of immune responses against specific antigens. In this study, we explored the effects of different immunization schedules on immune responses elicited by viral vector-based vaccines in monkeys, with a focus on the heterologous regimens with a next-generation attenuated vaccinia virus, Sementis Copenhagen vector (SCV), and human adenovirus serotype 26 (Ad26) expressing the Ebola glycoprotein (EBOV-GP). Our findings highlight that the order of administration of these vaccines plays a pivotal role in modulating cellular immune responses. We observed that initiating immunization with Ad26.EBOV followed by SCV.EBOV, significantly enhanced the magnitude and quality of antigen-specific memory CD4

Identifiers

PMID42177200
PMCPMC13473547

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.