Evidence map›Paper›PMID 42177196›Full record

Articlenpj aging2026

Osteocalcin is a compensatory hormone to protect the nervous system in ovariectomized mice.

Yiting Kang, Yaoyao Yao, Zeguo Feng, Xiaohang Gao, Yifei Song, Qianyu Zhang, Xiaohui Di, Lei Huang, Wei Han, Jianbao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yiting KangSchool of Physical Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yaoyao YaoKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zeguo FengKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaohang GaoKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yifei SongKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Qianyu ZhangKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaohui DiKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Lei HuangKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wei HanCollege of Forensic Science and Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. hanwei@mail.xjtu.edu.cn.
Jianbao ZhangKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. zhangjb@xjtu.edu.cn.

Funding

National Natural Science Foundation of China 11872297
6 · The paper itself

Abstract

Undercarboxylated osteocalcin (ucOCN), a bone-derived hormone, modulates neurocognition and emotional regulation. Its concentration declines with aging but rises secondarily in females with estrogen deficiency caused by ovarian decline. Using an ovariectomized (OVX) mouse model, we found serum ucOCN sharply increased in early OVX stages with normal behavioral performance, whereas prolonged estrogen loss decreased ucOCN and induced cognitive and emotional impairments. Ocn knockout mice failed to exhibit OVX-triggered ucOCN elevation and displayed severe synaptic damage and behavioral deficits at the early stage, which were rescued by exogenous ucOCN supplementation. Furthermore, long-term ucOCN administration ameliorated behavioral impairments induced by sustained estrogen deficiency, upregulated the expression of synaptic proteins, and restored hippocampal synaptic plasticity. Collectively, dynamic alterations in ucOCN are correlated with neurobehavioral changes under estrogen deficiency. As a time-dependent neurocompensatory mediator, ucOCN maintains hippocampal synaptic integrity. Long-term ucOCN intervention may provide a promising therapeutic strategy for estrogen deficiency-related cognitive and emotional disorders.

Identifiers

PMID42177196
PMCPMC13478390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.