Evidence map›Paper›PMID 42177187›Full record

ArticleNature communications2026

Counterfactual evaluation of elementary and secondary school policies in the COVID-19 pandemic.

Benedetta Canfora, Rey Audie Escosio, Otilia Boldea, Ana Nunes, Ganna Rozhnova

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benedetta Canfora *Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. benedetta.canfora@outlook.com.ORCID http://orcid.org/0009-0004-5948-844X
Rey Audie Escosio *Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-6802-017X
Otilia BoldeaDepartment of Econometrics and OR, Tilburg School of Economics and Management, Tilburg University, Tilburg, The Netherlands.ORCID http://orcid.org/0000-0002-6135-430X
Ana NunesBioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Lisbon, Portugal.
Ganna RozhnovaJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. g.rozhnova@umcutrecht.nl.ORCID http://orcid.org/0000-0002-6725-7359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the role of elementary and secondary schools in SARS-CoV-2 transmission is essential for designing effective public health policies. We developed a stochastic age-stratified transmission model, fitted to epidemiological and contact survey data, to evaluate how alternative school closure and reopening strategies might have shaped the course of the pandemic in the Netherlands from early 2020 through late 2021. Using counterfactual simulations and time-varying elasticity analysis, we found that school closures could mitigate transmission and reduce healthcare burden. However, their effectiveness was highly context-dependent, influenced by school type, contact patterns, policy timing, and population immunity. Age groups driving transmission shifted over time, with adults dominating early in the pandemic, adolescents in late 2020 and early 2021, and children in late 2021. Accordingly, secondary schools had a greater impact on national hospitalizations in 2020, while elementary schools became more important in 2021, partly due to lower infection-induced and negligible vaccine-induced immunity among children compared to adolescents. Together, these results underscore the importance of accounting for age-specific transmission dynamics and the evolving epidemiological landscape when evaluating school closure and reopening strategies. Our study supports a more targeted and adaptive approach to school policies in future pandemics.

Indexed as

COVID-19PandemicsSchoolsAdolescentChildHealth PolicyHumansNetherlandsSARS-CoV-2

Identifiers

PMID42177187
PMCPMC13385887

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.