SpEchinoidin, a C-type lectin and a member of an expanded CTL family, is up-regulated by phagocytes in sea urchins responding to immune challenge.

L Courtney Smith, Michael S Quesenberry, Keiko Saito, Keri Multerer, Gerardo R Vasta

Abstract read

In one paragraph

Article in Developmental and comparative immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

L Courtney SmithDepartment of Biological Sciences, George Washington University, Washington, DC, USA. Electronic address: csmith@gwu.edu.

Michael S QuesenberryDepartment of Microbiology and Immunology, University of Maryland School of Medicine and the Institute of Marine and Environmental Technology, University of Maryland, Baltimore, MD, USA.

Keiko SaitoDepartment of Microbiology and Immunology, University of Maryland School of Medicine and the Institute of Marine and Environmental Technology, University of Maryland, Baltimore, MD, USA.

Keri MultererGraduate Program in Genetics, George Washington University, Washington, DC, USA.

Gerardo R VastaDepartment of Microbiology and Immunology, University of Maryland School of Medicine and the Institute of Marine and Environmental Technology, University of Maryland, Baltimore, MD, USA. Electronic address: gvasta@som.umaryland.edu.

Funding

Biological Roles of GalectinsR01GM070589 · NIGMS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI VASTA, GERARDO RAUL · 2004 to 2013

$2.0M

NIGMS NIH HHS R01 GM070589

6 · The paper itself

Abstract

Transcript sequence analysis of coelomocytes from adult purple sea urchins (Strongylocentrotus purpuratus) responding to immune challenge identifies upregulated gene expression including two sequences that encode a C-type lectin (CTL) with a single carbohydrate recognition domain similar to HcEchinoidin from the sea urchin, Heliocidaris crassispina, and designated as SpEchinoidin. SpEchinoidin has a leader, an O-linked glycosylation site, and seven cysteines in conserved positions for CTLs. The mature SpEchinoidin is 18 kDa with conserved Ca

Indexed as

Lectins, C-TypePhagocytesSea UrchinsStrongylocentrotus purpuratusAmino Acid SequenceAnimalsImmunity, InnateMolecular Sequence DataPhylogenyUp-RegulationLectins, C-TypeBacterial challengeExpanded gene familyInducible lectinInnate immunityLipopolysaccharideStrongylocentrotus purpuratusSugar affinity isolation

Identifiers

PMID42176914

DOI10.1016/j.dci.2026.105629

PMCPMC13266792

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.