Evidence map›Paper›PMID 42176778›Full record

ArticleJournal of lipid research2026

Carnitine deficiency alters fuel metabolism and voluntary wheel running in mice.

Meagan S Kingren, Daniel G Sadler, Elijah Bolin, Izak Harville, James Sikes, Renny Lan, Elisabet Børsheim, Craig Porter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Meagan S KingrenDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA.
Daniel G SadlerDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA.
Elijah BolinDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA.
Izak HarvilleDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA.
James SikesArkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA.
Renny LanDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA.
Elisabet BørsheimDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA.
Craig PorterDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, Little Rock, AR, USA. Electronic address: CPorter@uams.edu.

Funding

The Role of the Mitochondrion in the Metabolic Stress Response to Burn TraumaP20GM109096 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI PORTER, CRAIG · 2016 to 2025
$20.7M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
The Role of the Mitochondrion in the Metabolic Stress Response to Burn TraumaR35GM142744 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI PORTER, CRAIG · 2021 to 2025
$2.0M
NIGMS NIH HHS P20 GM109096NIGMS NIH HHS R24 GM137786NIGMS NIH HHS R35 GM142744
6 · The paper itself

Abstract

Carnitine plays an obligatory role in energetics owing to its role in the translocation of long-chain fatty acids into the mitochondrion for oxidation. Here, we determined the metabolic and behavioral consequences of systemic carnitine deficiency (SCD) in mice. Female C57BL/6J mice were randomized to receive normal drinking water (control, n = 8) or drinking water supplemented with mildronate 4g

Indexed as

CarnitineEnergy MetabolismHyperammonemiaAnimalsCardiomyopathiesFemaleLiverMethylhydrazinesMiceMice, Inbred C57BLMuscle, SkeletalMuscular DiseasesOxidation-Reduction3-(2,2,2-trimethylhydrazine)propionateCarnitineMethylhydrazinesCarnitineenergy expenditureFat oxidationglucose oxidationMildronateMitochondriaSkeletal muscleStable Isotopessystemic carnitine deficiency

Identifiers

PMID42176778
PMCPMC13383224

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.