Evidence map›Paper›PMID 42176684›Full record

ArticleBreast (Edinburgh, Scotland)2026

Digital twins for non-invasive tumor localization in breast-conserving surgery: a technical pilot study.

Rafaela Timóteo, Alexandre Laborde, Bruno Vaz, Nuno Loução, Yasna Forghani, André Cardoso, Mariana Correia, João Santinha, Daniel Simões Lopes, Tiago Marques and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast (Edinburgh, Scotland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rafaela TimóteoSchool of Medicine, University of Lisbon, Av. Prof. Egas Moniz MB, 1649-028, Lisboa, Portugal; Breast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal.
Alexandre LabordeIT People, Praça Alvalade 7, 1700-345, Lisboa, Portugal.
Bruno VazIT People, Praça Alvalade 7, 1700-345, Lisboa, Portugal.
Nuno LouçãoBreast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal.
Yasna ForghaniSchool of Medicine, University of Lisbon, Av. Prof. Egas Moniz MB, 1649-028, Lisboa, Portugal; Breast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal.
André CardosoBreast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal.
Mariana CorreiaBreast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal.
João SantinhaSchool of Medicine, University of Lisbon, Av. Prof. Egas Moniz MB, 1649-028, Lisboa, Portugal; Breast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal.
Daniel Simões LopesITI/LARSyS, Av. Prof. Gama Pinto 2, 1649-003, Lisboa, Portugal; Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal.
Tiago MarquesSchool of Medicine, University of Lisbon, Av. Prof. Egas Moniz MB, 1649-028, Lisboa, Portugal; Breast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal. Electronic address: tiago.marques@research.fchampalimaud.org.
Pedro GouveiaSchool of Medicine, University of Lisbon, Av. Prof. Egas Moniz MB, 1649-028, Lisboa, Portugal; Breast Cancer Research Program, Champalimaud Foundation, Av Brasília, 1400-038, Lisboa, Portugal. Electronic address: pedro.gouveia@fundacaochampalimaud.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inaccurate tumor localization in breast-conserving surgery (BCS) can lead to positive margins and re-excision. In this technical pilot study, Digital Twins (DT) were used for non-invasive tumor localization in the operating room. Breast DTs were generated from supine breast magnetic resonance imaging and registered to patients in real-time using a 3D sensing system during four surgeries. Alignment accuracy was measured via nipple deviations (0-5 mm). Setup and marking times were clinically acceptable, with high perceived usability (SUS = 95). These preliminary results demonstrate the potential of integrating DTs into surgical workflows.

Indexed as

Breast NeoplasmsImaging, Three-DimensionalMagnetic Resonance ImagingMastectomy, SegmentalSurgery, Computer-AssistedFemaleHumansMiddle AgedPilot ProjectsBreast-conserving surgeryDigital twinsExtended realityTumor localization

Identifiers

PMID42176684
PMCPMC13224035

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.