Evidence map›Paper›PMID 42176457›Full record

ArticleChild abuse & neglect2026

Longitudinal patterns of threat- and deprivation-based childhood adversity and their impact on adolescent drinking, smoking, and depression.

Elizabeth Kwon, Damilola Adekunle, Hsien-Chang Lin, Su-Wei Wong, Matt Asare, Jae Woong Shim

Abstract read
In one paragraph

Article in Child abuse & neglect, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Elizabeth KwonDepartment of Public Health, Baylor University, Waco, TX, USA. Electronic address: Elizabeth_Kwon@baylor.edu.
Damilola AdekunleDepartment of Public Health, Baylor University, Waco, TX, USA.
Hsien-Chang LinDepartment of Child and Family Development, San Diego State University, San Diego, CA, USA.
Su-Wei WongDepartment of Public Health, National Taiwan University, Taipei, Taiwan.
Matt AsareDepartment of Public Health, Baylor University, Waco, TX, USA.
Jae Woong ShimSchool of Communication & Media, Sookmyung Women's University, Seoul, South Korea.

Funding

Pubertal development, stress system functioning, and addiction vulnerabilityK01DA060991 · NIDA · BAYLOR UNIVERSITY · PI Elizabeth Kwon · 2025 to 2026
$381k
NIDA NIH HHS K01 DA060991
6 · The paper itself

Abstract

purposeEmerging neuroimaging and biopsychological evidence suggests that adverse childhood experiences (ACEs) may have distinct effects on youth development depending on their type, timing, and duration. However, much of the existing research has emphasized cumulative exposure, often overlooking the unique characteristics of these experiences. The present study, therefore, aimed to (1) identify heterogeneous patterns of ACEs by accounting for both type and timing, and (2) examine the differential effects of these patterns on youth substance use and depression.

methodsWe used longitudinal data from the Fragile Families and Child Wellbeing Study (FFCWS) collected when youth were aged 3, 5, and 9 years. Longitudinal patterns of exposure to threat and deprivation were examined using parallel growth mixture modeling.

resultsWe identified four latent classes: (1) high-decreasing deprivation and high-decreasing threat; (2) low-stable deprivation and low-decreasing threat (minimal exposure group); (3) moderate-increasing deprivation and high-decreasing threat; and (4) low-stable deprivation and moderate-decreasing threat. Compared with class 2, youth in class 1, the group with the highest exposure had significantly higher risks of smoking, drinking, and depression at age 15. DISCUSSION: Youth outcomes are shaped not only by the cumulative severity of adversity but also by the types and timing of adversity across development. Findings from this study highlight that interventions may need to be tailored not only to the overall level of adversity a child experiences but also to the specific types and developmental timing of exposures.

Indexed as

Adverse Childhood ExperiencesDepressionSmokingUnderage DrinkingAdolescentChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleACEsAdolescentsDepressionDrinkingSmoking

Identifiers

PMID42176457
PMCPMC13262817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.