ArticlePlant physiology2026
Systemic acquired resistance signaling molecule N-hydroxypipecolic acid is involved in Age-related resistance in Arabidopsis thaliana.
Article in Plant physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Little is known about how mature Arabidopsis thaliana (Arabidopsis) plants become competent to initiate age-related resistance to normally virulent Pseudomonas syringae pv. tomato (Pst). RNA sequencing was used to identify genes that contribute to age-related resistance by comparing the response to Pst in young, susceptible plants 3.5 weeks postgermination with mature Age-related resistance-competent plants 6 weeks postgermination. Comparative transcriptomics revealed that age-related resistance shares many genes with pathogen-associated molecular pattern-triggered immunity, effector-triggered immunity, and systemic acquired resistance, providing additional evidence for the emerging idea that plant immune pathways are intertwined and interconnected. Age-related resistance-responding leaves expressed genes for the biosynthesis of N-hydroxypipecolic acid, a signaling molecule involved in systemic acquired resistance during the establishment of a primed state in systemic leaves. N-hydroxypipecolic acid biosynthesis mutants (ald1-1, fmo1-1) had age-related resistance defects and accumulated less intercellular salicylic acid than wild-type Col-0, indicating a requirement for functional N-hydroxypipecolic acid biosynthesis genes for intercellular salicylic acid accumulation during age-related resistance. Salicylic acid perception by NPR1/4 proteins was required for age-related resistance, as demonstrated by the age-related resistance-defective phenotype of the salicylic acid-signaling mutant, npr1-1 npr4-4D. N-hydroxypipecolic acid biosynthesis genes were still expressed in npr1-1 npr4-4D, suggesting that, similar to systemic acquired resistance, N-hydroxypipecolic acid functions upstream of NPR1-mediated signaling during age-related resistance. Unlike age-related resistance-incompetent plants (3, 4, 5 weeks postgermination untreated), age-related resistance-competent plants (6 weeks postgermination untreated) expressed N-hydroxypipecolic acid biosynthesis genes, accumulated N-hydroxypipecolic acid, and expressed immunity-associated cell surface receptors RLP23 and RLP28, supporting the idea that N-hydroxypipecolic acid contributes to initiating a developmentally controlled age-related resistance-competent primed state in mature Arabidopsis that is similar to the primed state established in distant leaves during systemic acquired resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.